AV-105

• CAT Number: I015363
• CAS Number: 1205550-99-7
• Molecular Formula: C32H40N2O8S
• Molecular Weight: 612.73
• Purity: ≥95%
• Synonyms: 2-[2-[2-[5-[(E)-2-[4-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]phenyl]ethenyl]pyridin-2-yl]oxyethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
• InChI: InChI=1S/C32H40N2O8S/c1-25-6-15-29(16-7-25)43(36,37)41-23-21-39-19-18-38-20-22-40-30-17-12-27(24-33-30)9-8-26-10-13-28(14-11-26)34(5)31(35)42-32(2,3)4/h6-17,24H,18-23H2,1-5H3/b9-8+
• InChIKey: MDBUGPWBKWJULZ-CMDGGOBGSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOC2=NC=C(C=C2)/C=C/C3=CC=C(C=C3)N(C)C(=O)OC(C)(C)C

AV-105（Cat No.:I015363）is a small-molecule inhibitor designed to target hypoxia-inducible factor prolyl hydroxylase (HIF-PHD), enzymes responsible for regulating the stability of hypoxia-inducible factors (HIFs). By inhibiting PHD activity, AV-105 stabilizes HIF-α subunits, promoting transcription of genes involved in erythropoiesis, angiogenesis, and cellular adaptation to low oxygen. This mechanism positions AV-105 as a potential therapeutic candidate for anemia and ischemic disorders. In research, it is used to explore hypoxia signaling pathways, oxygen-sensing mechanisms, and novel strategies for treating conditions associated with impaired oxygen delivery or red blood cell production.