Aurora Kinases-IN-3

• CAT Number: I042455
• CAS Number: 2840558-83-8
• Molecular Formula: C20H16F3N3O4
• Molecular Weight: 419.35
• Purity: ≥95%
• Synonyms: 3-[3-(2-methoxypyridin-4-yl)pyridin-2-yl]oxy-N-methyl-5-(trifluoromethoxy)benzamide
• InChI: InChI=1S/C20H16F3N3O4/c1-24-18(27)13-8-14(11-15(9-13)30-20(21,22)23)29-19-16(4-3-6-26-19)12-5-7-25-17(10-12)28-2/h3-11H,1-2H3,(H,24,27)
• InChIKey: NVMJCTQSUKIXBG-UHFFFAOYSA-N
• SMILES: CNC(=O)C1=CC(=CC(=C1)OC(F)(F)F)OC2=C(C=CC=N2)C3=CC(=NC=C3)OC

Aurora Kinases-IN-3 (Cat No.: I042455) is a potent and selective small molecule inhibitor targeting Aurora kinases, key regulators of mitosis and cell division. By inhibiting Aurora A, B, and/or C kinases, it disrupts proper chromosome alignment, segregation, and cytokinesis, leading to cell cycle arrest and apoptosis. Aurora Kinases-IN-3 is widely used in cancer research to explore mitotic control mechanisms and evaluate novel therapeutic strategies for tumors characterized by high proliferative activity. Its selectivity and efficacy make it a valuable experimental tool.

Reference

[1]. Lv G, et al. 2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114904.
[Content Brief]