Aurora Kinase Inhibitor III

• CAT Number: R067031
• CAS Number: 879127-16-9
• Molecular Formula: C21H18F3N5O
• Molecular Weight: 413.4
• Purity: ≥95%
• Synonyms: C-1368;INH 1
• Storage: 2-8°C
• IUPAC Name: N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide
• InChI: InChI=1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29)
• InChIKey: RDTDWGQDFJPTPD-UHFFFAOYSA-N
• SMILES: C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=CC(=N3)NC4=CC=CC(=C4)C(F)(F)F

Aurora kinase inhibitor III（Cat No.:R067031） is a highly effective inhibitor of Aurora A kinase, with an IC50 value of 42 nM. It also exhibits activity against other kinases, with IC50 values of 386 nM, 3550 nM, 591 nM, 1980 nM, 2510 nM, 887 nM, and >10,000 nM for BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR, respectively. This inhibitor shows selectivity for Aurora A kinase and offers potential for targeted cancer therapies by inhibiting cell division and proliferation pathways associated with Aurora A kinase.