Atropine sulfate monohydrate

• CAT Number: A001056
• CAS Number: 5908-99-6
• Molecular Formula: 2(C17H23NO3).H2O.H2SO4
• Molecular Weight: 694.83
• Purity: ≥95%
• Target: AChR
• Solubility: Soluble in DMSO > 10 mM
• Storage: 3 years -20C powder

Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.Atropine increases the release of the neurotransmitter dopamine into the superfusate in vitro at 100-500 mM and into the vitreous in vivo at 250 mg. Atropine induces spreading depression (SD) in the in vitro preparation. Atropine reduces the ERG b- and d-wave, leads to damped oscillations of RPE potentials, and reverses the ERG c-wave. Atropine suppresses myopia only at doses at which severe nonspecific side effects are observed in the retina.Atropine (1.0 mg/kg, i.p.), but not methylatropine (1.0 mg/kg, i.p.), prevents the enhancement of retention induced by both doses of the anticholinesterase when given immediately after training in mice.