Atropine sulfate

• CAT Number: I004066
• CAS Number: 55-48-1
• Molecular Formula: C17H23NO3 . 1/2 H2O4S
• Molecular Weight: 338.41
• Purity: ≥95%
• Target: mAChR
• Solubility: 10 mM in H2O (free soluble)
• Storage: Store at -20°C
• InChI: InChI=1S/2C17H23NO3.H2O4S/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4)
• InChIKey: HOBWAPHTEJGALG-UHFFFAOYSA-N
• SMILES: CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.OS(=O)(=O)O

Atropine sulfate (Cat.No:I004066), a medication derived from the plant Atropa belladonna, is used to treat bradycardia (slow heart rate) and certain types of spasms in the digestive and urinary tracts. It works by blocking acetylcholine receptors in the body. Atropine sulfate is administered by injection or through an inhaler for certain respiratory conditions.

Reference

1:Formulation and Evaluation of Fast-Disintegrating Sublingual Tablets of Atropine Sulfate: the Effect of Tablet Dimensions and Drug Load on Tablet Characteristics. Aodah A, Bafail RS, Rawas-Qalaji M.AAPS PharmSciTech. 2016 Sep 20. [Epub ahead of print] PMID: 27650282 2:Assessment of drug content uniformity of atropine sulfate triturate by liquid chromatography-tandem mass spectrometry, X-ray powder diffraction, and Raman chemical imaging. Moriyama K, Takami Y, Uozumi N, Okuda A, Yamashita M, Yokomizo R, Shimada K, Egawa T, Kamei T, Takayanagi K.J Pharm Health Care Sci. 2016 Feb 10;2:4. doi: 10.1186/s40780-016-0038-7. eCollection 2016. PMID: 26865984 Free PMC Article3:Formulation and characterization of atropine sulfate in albumin-chitosan microparticles for in vivo ocular drug delivery. Addo RT, Yeboah KG, Siwale RC, Siddig A, Jones A, Ubale RV, Akande J, Nettey H, Patel NJ, Addo E, D/’Souza MJ.J Pharm Sci. 2015 May;104(5):1677-90. doi: 10.1002/jps.24380. Epub 2015 Feb 4. PMID: 25652269 4:Atropine sulfate for treatment of bradycardia in a patient with morbid obesity: what may happen when you least expect it. Carron M, Veronese S.BMJ Case Rep. 2015 Jan 29;2015. pii: bcr2014207596. doi: 10.1136/bcr-2014-207596. PMID: 25634857 Free PMC Article5:Determination of atropine sulfate using a novel sensitive DNA-biosensor based on its interaction on a modified pencil graphite electrode. Ensafi AA, Nasr-Esfahani P, Heydari-Bafrooei E, Rezaei B.Talanta. 2015 Jan;131:149-55. doi: 10.1016/j.talanta.2014.07.082. Epub 2014 Aug 12. PMID: 25281086 6:Comparison of the effects of topical and systemic atropine sulfate on intraocular pressure and pupil diameter in the normal canine eye. Kovalcuka L, Birgele E, Bandere D, Williams DL.Vet Ophthalmol. 2015 Jan;18(1):43-9. doi: 10.1111/vop.12138. Epub 2014 Jan 16. PMID: 24428364 7:[Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC]. Zhang YL, Li YP.Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3291-4. Chinese. PMID: 24422394 8:Quantitative proton nuclear magnetic resonance for the structural and quantitative analysis of atropine sulfate. Shen S, Yao J, Shi Y.J Pharm Biomed Anal. 2014 Feb;89:118-21. doi: 10.1016/j.jpba.2013.10.036. Epub 2013 Nov 7. PMID: 24280740 9:Development of a combined solution formulation of atropine sulfate and obidoxime chloride for autoinjector and evaluation of its stability. Ettehadi HA, Ghalandari R, Shafaati A, Foroutan SM.Iran J Pharm Res. 2013 Winter;12(Suppl):31-6. PMID: 24250669 Free PMC Article10:Catalytic activity of ruthenium(III) on the oxidation of an anticholinergic drug-atropine sulfate monohydrate by copper(III) periodate complex in aqueous alkaline medium – decarboxylation and free radical mechanism. Byadagi KS, Nandibewoor ST, Chimatadar SA.Acta Chim Slov. 2013;60(3):617-27. PMID: 24169716