Atomoxetine HCl

• CAT Number: A001162
• CAS Number: 82248-59-7
• Molecular Formula: C17H21NO.HCl
• Molecular Weight: 291.82
• Purity: ≥95%
• Synonyms: LY 139603 HCl
• Target: Neuronal Signaling
• Storage: 3 years -20C powder
• IUPAC Name: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride
• InChI: InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
• InChIKey: LUCXVPAZUDVVBT-UNTBIKODSA-N
• SMILES: CC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.[H]Cl

Atomoxetine HCl (Cat No.: A001162) is a selective norepinephrine reuptake inhibitor (NRI) used primarily to treat attention-deficit/hyperactivity disorder (ADHD) in children, adolescents, and adults. Unlike stimulants, it is non-addictive and works by increasing norepinephrine levels in the brain, which helps improve attention, focus, and impulse control. Atomoxetine is taken orally and typically requires several weeks for full therapeutic effect. Common side effects include dry mouth, decreased appetite, fatigue, and insomnia. It may also increase blood pressure or cause mood changes in some individuals.

Reference

1:J Pharm Sci. 2006 Aug;95(8):1677-83. Structural determination of the stable and meta-stable forms of atomoxetine HCl using single crystal and powder X-ray diffraction methods.Stephenson GA,Liang C, PMID: 16732589 DOI: 10.1002/jps.20643 Abstract: Stratteratrade mark is the first FDA-approved nonstimulant medication for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children, adolescents, and adults. Two polymorphic forms and an amorphous form of the active pharmaceutical ingredient, atomoxetine HCl, were discovered during drug development. The thermodynamically stable polymorphic form was selected for the commercial product. The stable form readily grows as crystals suitable for single crystal diffraction. The meta-stable crystal form is isolated by rapid crystallization, providing crystals that are too small for routine single crystal methods; consequently its structure was determined by X-ray powder diffraction.Copyright 2006 Wiley-Liss, Inc.