ATM Kinase Inhibitor, KU-55933

• CAT Number: I004201
• CAS Number: 587871-26-9
• Molecular Formula: C₂₁H₁₇NO₃S₂
• Molecular Weight: 395.49
• Purity: ≥95%
• Target: ATM/ATR
• Solubility: 10 mM in DMSO
• Storage: 3 years -20℃ powder
• IC50: 13 nM
• IUPAC Name: 2-morpholin-4-yl-6-thianthren-1-ylpyran-4-one
• InChI: InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
• InChIKey: XRKYMMUGXMWDAO-UHFFFAOYSA-N
• SMILES: C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

KU-55933 (Cat.No:I004201) is a potent and selective ATM kinase inhibitor with an IC50 of 13 nM. It has been shown to enhance the cytotoxicity of ionizing radiation and chemotherapy in preclinical models, making it a promising therapeutic agent for cancer treatment. KU-55933 is also widely used in DNA damage response research.

Reference

1:The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D. Chwastek J, Jantas D, Lasoń W.Int J Biochem Cell Biol. 2017 Mar 21;87:38-53. doi: 10.1016/j.biocel.2017.03.015. [Epub ahead of print] PMID: 28341201 2:Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin. Zakikhani M, Bazile M, Hashemi S, Javeshghani S, Avizonis D, St Pierre J, Pollak MN.PLoS One. 2012;7(11):e49513. doi: 10.1371/journal.pone.0049513. Epub 2012 Nov 21. PMID: 23185347 Free PMC Article3:ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. Nadkarni A, Shrivastav M, Mladek AC, Schwingler PM, Grogan PT, Chen J, Sarkaria JN.J Neurooncol. 2012 Dec;110(3):349-57. doi: 10.1007/s11060-012-0979-0. Epub 2012 Oct 3. PMID: 23054561 Free PMC Article4:The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt. Li Y, Yang DQ.Mol Cancer Ther. 2010 Jan;9(1):113-25. doi: 10.1158/1535-7163.MCT-08-1189. Epub 2010 Jan 6. PMID: 20053781 Free Article