AT-406 HCl

• CAT Number: I022584
• CAS Number: 1071992-57-8
• Molecular Formula: C32H44ClN5O4
• Molecular Weight: 597.31
• Purity: 98%
• Synonyms: AT-406 HCl; DeBio-1143; DeBio1143; DeBio 1143; AT-406; AT406; AT 406; SM 406; SM406; ARRY-334543; ARRY334543; ARRY 334543.
• Solubility: Soluble in DMSO
• Storage: Store at -20°C, sealed storage, away from moisture and light
• IUPAC Name: (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide hydrochloride
• InChI: InChI=1S/C32H43N5O4.ClH/c1-21(2)19-28(38)36-18-17-25-15-16-27(37(25)32(41)26(20-36)34-30(39)22(3)33-4)31(40)35-29(23-11-7-5-8-12-23)24-13-9-6-10-14-24;/h5-14,21-22,25-27,29,33H,15-20H2,1-4H3,(H,34,39)(H,35,40);1H/t22-,25+,26-,27-;/m0./s1
• InChIKey: DBXTZCYPHKJCHF-ZZPLZQMBSA-N
• SMILES: O=C([C@@H]1CC[C@@](CCN(C(CC(C)C)=O)C[C@@H]2NC([C@@H](NC)C)=O)([H])N1C2=O)NC(C3=CC=CC=C3)C4=CC=CC=C4.[H]Cl

AT-406 HCl（Cat No.:I022584） is a small molecule inhibitor of multiple anti-apoptotic proteins, including IAP family members (cIAP1, cIAP2, and XIAP) and the Bcl-2 family member, Mcl-1. It acts by disrupting the interaction between these proteins and pro-apoptotic factors, leading to the activation of the intrinsic apoptotic pathway. AT-406 HCl has been shown to have anti-tumor activity in preclinical studies and is being investigated as potential cancer therapeutic.

Reference

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