AT-130

• CAT Number: I003020
• CAS Number: 211364-06-6
• Molecular Formula: C22H22BrN3O5
• Molecular Weight: 488.338
• Purity: ≥95%
• Synonyms: AT-130; AT 130; AT130.;(E)-N-(1-bromo-1-(2-methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)-4-nitrobenzamide
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term or -20 °C for long term
• InChI: InChI=1S/C22H22BrN3O5/c1-31-18-8-4-3-7-17(18)19(23)20(22(28)25-13-5-2-6-14-25)24-21(27)15-9-11-16(12-10-15)26(29)30/h3-4,7-12H,2,5-6,13-14H2,1H3,(H,24,27)/b20-19+
• InChIKey: OQIUTYABZMBBME-FMQUCBEESA-N
• SMILES: O=C(N/C(C(N1CCCCC1)=O)=C(Br)C2=CC=CC=C2OC)C3=CC=C([N+]([O-])=O)C=C3

AT-130 is a HBV virus inhibitor. AT-130 has improved potency of IC50 of 0.13 μM and reduced toxicity in the HepAD38 cell line. AT-130 blocks HBV replication at the level of viral RNA packaging. AT-130 could be a potential alternative agent for HCV treatment.

Reference

1:Raman spectroscopy for the characterization of different fractions of hemp essential oil extracted at 130°C using steam distillation method. Hanif MA, Nawaz H, Naz S, Mukhtar R, Rashid N, Bhatti IA, Saleem M.Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jul 5;182:168-174. doi: 10.1016/j.saa.2017.03.072. Epub 2017 Apr 1. PMID: 28431313 2:Structure and Variability of the North Equatorial Current/Undercurrent from Mooring Measurements at 130°E in the Western Pacific. Zhang L, Wang FJ, Wang Q, Hu S, Wang F, Hu D.Sci Rep. 2017 Apr 19;7:46310. doi: 10.1038/srep46310. PMID: 28422095 Free PMC Article3:Genetic stability of ectomycorrhizal fungi is not affected by cryopreservation at -130 °C or cold storage with repeated sub-cultivations over a period of 2 years. Crahay C, Munaut F, Colpaert JV, Huret S, Declerck S.Mycorrhiza. 2017 Mar 30. doi: 10.1007/s00572-017-0770-3. [Epub ahead of print] PMID: 28361204 4:Crystal structures of morpholinium hydrogen bromanilate at 130, 145 and 180 K. Gotoh K, Tahara Y, Ishida H.Acta Crystallogr E Crystallogr Commun. 2015 Sep 26;71(Pt 10):1226-9. doi: 10.1107/S2056989015017272. eCollection 2015 Oct 1. PMID: 26594413 Free PMC Article5:Preparation of copper nitride (Cu3N) nanoparticles in long-chain alcohols at 130-200 °C and nitridation mechanism. Nakamura T, Hayashi H, Hanaoka TA, Ebina T.Inorg Chem. 2014 Jan 21;53(2):710-5. doi: 10.1021/ic4011604. Epub 2013 Dec 26. PMID: 24369736 6:Thermal comfort and safety of cotton blankets warmed at 130°F and 200°F. Kelly PA, Cooper SK, Krogh ML, Morse EC, Crandall CG, Winslow EH, Balluck JP.J Perianesth Nurs. 2013 Dec;28(6):337-46. doi: 10.1016/j.jopan.2012.10.007. PMID: 24267621 7:MRI of the human brain at 130 microtesla. Inglis B, Buckenmaier K, Sangiorgio P, Pedersen AF, Nichols MA, Clarke J.Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19194-201. doi: 10.1073/pnas.1319334110. Epub 2013 Nov 19. PMID: 24255111 Free PMC Article8:Anomalous temperature dependence of phonons and photoluminescence bands in pyrochlore Er2Ti2O7: signatures of structural deformation at 130 K. Saha S, Prusty S, Singh S, Suryanarayanan R, Revcolevschi A, Sood AK.J Phys Condens Matter. 2011 Nov 9;23(44):445402. doi: 10.1088/0953-8984/23/44/445402. Epub 2011 Oct 18. PMID: 22004888 9:The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packaging. Feld JJ, Colledge D, Sozzi V, Edwards R, Littlejohn M, Locarnini SA.Antiviral Res. 2007 Nov;76(2):168-77. Epub 2007 Jul 24. PMID: 17709147 10:Brucine salts of L-alpha-hydroxy acids: brucinium hydrogen (S)-malate pentahydrate and anhydrous brucinium hydrogen (2R,3R)-tartrate at 130 K. Smith G, Wermuth UD, White JM.Acta Crystallogr C. 2006 Jun;62(Pt 6):o353-7. Epub 2006 May 24. PMID: 16763326