ASK1-IN-1

• CAT Number: I001054
• CAS Number: 1262041-49-5
• Molecular Formula: C23H21N7O
• Molecular Weight: 411.46
• Purity: ≥95%
• Target: ASK1[1]
• Solubility: DMSO: ≤ 15.5 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 4-(4-cyclopropylimidazol-1-yl)-N-[3-(4-cyclopropyl-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide
• InChI: InChI=1S/C23H21N7O/c31-23(20-11-19(8-9-24-20)29-12-21(25-13-29)15-4-5-15)27-17-3-1-2-16(10-17)22-28-26-14-30(22)18-6-7-18/h1-3,8-15,18H,4-7H2,(H,27,31)
• InChIKey: ZGCMQKWOUIMBEP-UHFFFAOYSA-N
• SMILES: C1CC1C2=CN(C=N2)C3=CC(=NC=C3)C(=O)NC4=CC=CC(=C4)C5=NN=CN5C6CC6

GS-444217（Cat No.:I001054）, also known as ASK1-IN-1, is a highly potent, selective, and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1). It acts as an ATP-competitive inhibitor with an impressive IC50 value of 2.87 nM. ASK1 plays a critical role in regulating cellular responses to stress and apoptosis. By inhibiting ASK1, GS-444217 has the potential to modulate cellular signaling pathways and may have therapeutic applications in conditions where ASK1 dysregulation is implicated, such as neurodegenerative diseases and inflammatory disorders.

Reference

[1].
Grant Raymond BUDAS, et al. Methods of treating pulmonary hypertension. WO2016025474A1.