Asiaticoside

• CAT Number: R039721
• CAS Number: 16830-15-2
• Molecular Formula: C48H78O19
• Molecular Weight: 959.1
• Purity: ≥95%
• Storage: 4°C
• InChI: InChI=1S/C48H78O19/c1-20-10-13-48(15-14-46(6)23(29(48)21(20)2)8-9-28-44(4)16-24(51)39(60)45(5,19-50)27(44)11-12-47(28,46)7)43(61)67-42-36(58)33(55)31(53)26(65-42)18-62-40-37(59)34(56)38(25(17-49)64-40)66-41-35(57)32(54)30(52)22(3)63-41/h8,20-22,24-42,49-6
• InChIKey: WYQVAPGDARQUBT-FGWHUCSPSA-N
• SMILES: OC[C@]1(C)[C@@H](O)[C@H](O)C[C@@]2(C)[C@@]1([H])CC[C@]3(C)[C@]2([H])CC=C4[C@@]3(C)CC[C@]5(C(O[C@@H]6O[C@H](CO[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@]8([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](CO)O7)[C@@H](O)[C@H](O)[C@H]6O)=O)[C@@]4([H])[C@@H](C)[C@

Asiaticoside is a skin whiening agent found in Cetella. It decreases DNA binding by MITF. It also induces apoptosis in breast cancer cells, improves memory and learning deficits, decreases release of pro-inflammatory cytokines, and suppresses LPS-induced inflammation and fever.

Reference

1:Asiaticoside ameliorates β-amyloid-induced learning and memory deficits in rats by inhibiting mitochondrial apoptosis and reducing inflammatory factors. Zhang Z, Li X, Li D, Luo M, Li Y, Song L, Jiang X.Exp Ther Med. 2017 Feb;13(2):413-420. doi: 10.3892/etm.2016.4004. Epub 2016 Dec 27. PMID: 28352309 Free PMC Article2:Asiaticoside hinders the invasive growth of keloid fibroblasts through inhibition of the GDF-9/MAPK/Smad pathway. Wu X, Bian D, Dou Y, Gong Z, Tan Q, Xia Y, Dai Y.J Biochem Mol Toxicol. 2017 Mar 27. doi: 10.1002/jbt.21922. [Epub ahead of print] PMID: 28346732 3:Borneol enhances the antidepressant effects of asiaticoside by promoting its distribution into the brain. Hou T, Li X, Peng C.Neurosci Lett. 2017 Apr 12;646:56-61. doi: 10.1016/j.neulet.2017.02.068. Epub 2017 Mar 3. PMID: 28263826 4:Asiaticoside: Attenuation of rotenone induced oxidative burden in a rat model of hemiparkinsonism by maintaining the phosphoinositide-mediated synaptic integrity. Gopi M, Arambakkam Janardhanam V.Pharmacol Biochem Behav. 2017 Apr;155:1-15. doi: 10.1016/j.pbb.2017.02.005. Epub 2017 Feb 24. PMID: 28238857 5:Asiaticoside protects cochlear hair cells from high glucose-induced oxidative stress via suppressing AGEs/RAGE/NF-κB pathway. Xing Y, Ji Q, Li X, Ming J, Zhang N, Zha D, Lin Y.Biomed Pharmacother. 2017 Feb;86:531-536. doi: 10.1016/j.biopha.2016.12.025. Epub 2016 Dec 23. PMID: 28024288 6:Comparative pharmacokinetics between madecassoside and asiaticoside presented in a standardised extract of Centella asiatica, ECa 233 and their respective pure compound given separately in rats. Hengjumrut P, Anukunwithaya T, Tantisira MH, Tantisira B, Khemawoot P.Xenobiotica. 2017 Jan 18:1-10. doi: 10.1080/00498254.2016.1273562. [Epub ahead of print] PMID: 28001462 7:Preparation of asiaticoside-loaded coaxially electrospinning nanofibers and their effect on deep partial-thickness burn injury. Zhu L, Liu X, Du L, Jin Y.Biomed Pharmacother. 2016 Oct;83:33-40. doi: 10.1016/j.biopha.2016.06.016. Epub 2016 Jun 20. PMID: 27470547 8:Porous microspheres as promising vehicles for the topical delivery of poorly soluble asiaticoside accelerate wound healing and inhibit scar formation in vitro &in vivo. Zhang CZ, Niu J, Chong YS, Huang YF, Chu Y, Xie SY, Jiang ZH, Peng LH.Eur J Pharm Biopharm. 2016 Dec;109:1-13. doi: 10.1016/j.ejpb.2016.09.005. Epub 2016 Sep 8. PMID: 27614186 9:Burn wound healing properties of asiaticoside and madecassoside. Hou Q, Li M, Lu YH, Liu DH, Li CC.Exp Ther Med. 2016 Sep;12(3):1269-1274. Epub 2016 Jun 16. PMID: 27588048 Free PMC Article10:Effect of Asiaticoside, Collagenase, and Alpha-chymotrypsin on Wound Healing in Rabbits. Ozdemir O, Ozkan K, Hatipoglu F, Uyaroglu A, Arican M.Wounds. 2016 Aug;28(8):279-86. PMID: 27560471 Free Article