AS101

• CAT Number: M009679
• CAS Number: 106566-58-9
• Molecular Formula: C2H4Cl3O2Te.NH4
• Molecular Weight: 312.05
• Purity: ≥95%
• Target: Others
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C2H4Cl3O2Te.H3N/c3-8(4,5)6-1-2-7-8;/h1-2H2;1H3/q-1;/p+1
• InChIKey: AXWLPMGUUAIGJK-UHFFFAOYSA-O
• SMILES: Cl[Te-]1(Cl)(Cl)OCCO1.[NH4+]

AS101, also known as Ossirene, is a synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. Ammonium trichlorotellurate may inhibit the inflammatory cytokine interleukin-10 (IL-10) and may induce hematopoietic cells to express interleukin-2 (IL-2), IL-2 receptors, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, tumor necrosis factor (TNF) and interferons (INFs). This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced myelosuppression. In addition, this agent exhibits hair growth-promoting activity by inducing anagen production and inhibiting catagen production, resulting in the promotion of follicular keratinocyte proliferation and interference with follicular keratinocyte terminal differentiation, respectively. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia.

Reference

1:The immunomodulator, ammonium trichloro[1,2-ethanediolato-O,O/’]-tellurate, suppresses the propagation of herpes simplex virus 2 by reducing the infectivity of the virus progeny. Sheinboim D, Hindiyeh M, Mendelson E, Albeck M, Sredni B, Dovrat S.Int J Mol Med. 2015 Jul;36(1):231-8. doi: 10.3892/ijmm.2015.2197. Epub 2015 Apr 24. PMID: 25936393
2:Novel microwave-assisted synthesis of the immunomodulator organotellurium compound ammonium trichloro(dioxoethylene-O,O/’)tellurate (AS101). Vázquez-Tato MP, Mena-Menéndez A, Feás X, Seijas JA.Int J Mol Sci. 2014 Feb 21;15(2):3287-98. doi: 10.3390/ijms15023287. PMID: 24566150 Free PMC Article