Aristolochic Acid B

• CAT Number: R008257
• CAS Number: 475-80-9
• Molecular Formula: C16H9NO6
• Molecular Weight: 311.249
• Purity: ≥95%
• Synonyms: 6-Nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic Acid; Aristolochic Acid II;?3,4-(Methylenedioxy)-10-nitrophenanthrene-1-carboxylic Acid
• Target: PLA2 inhibitor
• Storage: -20°C
• IUPAC Name: 6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
• InChI: InChI=1S/C16H9NO6/c18-16(19)10-6-12-15(23-7-22-12)14-9-4-2-1-3-8(9)5-11(13(10)14)17(20)21/h1-6H,7H2,(H,18,19)
• InChIKey: MEEXETVZNQYRSP-UHFFFAOYSA-N
• SMILES: C1OC2=C(O1)C3=C(C(=C2)C(=O)O)C(=CC4=CC=CC=C43)[N+](=O)[O-]

Aristolochic acid B is a carcinogen found in Aristolochia and Radix. It inhibits PLA2.

Reference

1: Liu Y, Han S, Feng Q, Wang J. [Determination of aristolochic acids A and B in Chinese herbals and traditional Chinese patent medicines using ultra high performance liquid chromatography-triple quadrupole mass spectrometry]. Se Pu. 2011 Nov;29(11):1076-81. Chinese. PubMed PMID: 22393694.2: Mou ZL, Qi XN, Liu RL, Zhang J, Zhang ZQ. Three-dimensional cell bioreactor coupled with high performance liquid chromatography-mass spectrometry for the affinity screening of bioactive components from herb medicine. J Chromatogr A. 2012 Jun 22;1243:33-8. doi: 10.1016/j.chroma.2012.04.041. Epub 2012 Apr 19. PubMed PMID: 22554414.