Arglabin

• CAT Number: I005070
• CAS Number: 84692-91-1
• Molecular Formula: C₁₅H₁₈O₃
• Molecular Weight: 246.3
• Purity: ≥95%
• Target: anticancer
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C15H18O3/c1-8-4-7-15-11(8)12-10(9(2)13(16)17-12)5-6-14(15,3)18-15/h4,10-12H,2,5-7H2,1,3H3/t10-,11-,12-,14-,15+/m0/s1
• InChIKey: UVJYAKBJSGRTHA-ZCRGAIPPSA-N
• SMILES: CC1=CCC23C1C4C(CCC2(O3)C)C(=C)C(=O)O4

Arglabin (Cat.No:I005070), also known as (+)-13-epi-manoyl oxide, is a natural sesquiterpene lactone found in many plants, including Artemisia glabella. It exhibits a range of biological activities, including antitumor, antifungal, and antiparasitic effects. Arglabin has shown potential as a chemotherapy adjuvant and as a treatment for parasitic infections, including malaria. Its chemical structure has been the subject of numerous synthetic studies.

Reference

[1]. Bottex-Gauthier C, et al. In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall. (Asteraceae). Biotechnol Ther. 1993;4(1-2):77-98.
[2]. Abil/’daeva AZh, et al. Anti-inflammatory effect of arglabin and 11,13-dihydro-13-dimethylaminoarglabin hydrochloride. Eksp Klin Farmakol. 2004 Jan-Feb;67(1):37-9.
[3]. Zhang Q, et al. Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells. J Med Chem. 2012 Oct 25;55(20):8757-69.