argiotoxin 636

• CAT Number: M007513
• CAS Number: 108687-79-2
• Molecular Formula: C29H52N10O6
• Molecular Weight: 636.799
• Purity: ≥95%
• Storage: -80°C
• Related CAS: 105029-41-2
• IUPAC Name: (2S)-N-[5-[3-[3-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propylamino]propylamino]pentyl]-2-[[2-(2,4-dihydroxyphenyl)acetyl]amino]butanediamide
• InChI: InChI=1S/C29H52N10O6/c30-22(7-4-15-38-29(32)33)27(44)36-16-6-13-35-12-5-11-34-10-2-1-3-14-37-28(45)23(19-25(31)42)39-26(43)17-20-8-9-21(40)18-24(20)41/h8-9,18,22-23,34-35,40-41H,1-7,10-17,19,30H2,(H2,31,42)(H,36,44)(H,37,45)(H,39,43)(H4,32,33,38)/t22-,23-/m0/s1
• InChIKey: FTNICLJXPYLDAH-GOTSBHOMSA-N
• SMILES: C1=CC(=C(C=C1O)O)CC(=O)NC(CC(=O)N)C(=O)NCCCCCNCCCNCCCNC(=O)C(CCCN=C(N)N)N

Argiotoxin 636 (Cat.No:M007513) is a neurotoxin isolated from the venom of the spider Argiope lobata. It acts as a potent and selective blocker of P-type voltage-gated calcium channels (CaV2.1 channels). This toxin is widely used in neuroscience research to study the role of CaV2.1 channels in synaptic transmission and neurological disorders.

Reference

– Jackson et al., /Spider toxins as tools for dissecting elements of excitatory transmission./ TINS (1988). 11(6):278-283

– Magazanik et al., /Argiopin – a naturally occuring blocker of glutamate-sensitive synaptic channels./ Receptors and Ion Channels. de Gruyter. Berlin. (1987). 305-312

– Antonov et al., Neuroscience Letters, (1987). 83:179-184

– Lodge et al., /Non-competitive excitatory amino acid receptor antagonists./ TIPS (1990). 11:81-86

– Priestley et al., /Antagonism of responses to excitatory amino acids on rat cortical neurons by the spider toxin, Argiotoxin 636./ Br. J. Pharmacol. (1989). 97:1315-1323