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Arachidonic Acid Glycidyl Ester

Arachidonic Acid Glycidyl Ester

  • CAT Number: R039534
  • CAS Number: 439146-24-4
  • Molecular Formula: C23H36O3
  • Molecular Weight: 360.5
  • Purity: ≥95%
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2-<wbr></wbr>Arachidonoyl glycerol (2-<wbr></wbr>AG) is an endogenous ligand that binds to both central cannabinoid (CB<sub>1</sub>) and peripheral cannabinoid (CB<sub>2</sub>) receptors and is involved in the regulation of a broad range of neurotransmitter signalling functions with implications in neurodegenerative diseases, pain, cancer, and obesity. Levels of this endocannabinoid are regulated by hydrolysis to glycerol and arachidonic acid by the enzyme monoacylglycerol lipase. O-<wbr></wbr>Arachidonoyl glycidol is a 2-<wbr></wbr>arachidonoyl glycerol analog that blocks 2-<wbr></wbr>oleoyl glycerol hydrolysis in the cytosolic and membrane fractions of rat cerebella with IC<sub>50</sub> values of 4.5 and 19 µM, respectively. O-<wbr></wbr>Arachidonoyl glycidol inhibits fatty acid amide hydrolase-<wbr></wbr>catalyzed hydrolysis of arachidonoyl ethanolamide in the membrane fraction of rat cerebella with an IC<sub>50</sub> value of 12 µM.

Catalog Number R039534
CAS Number 439146-24-4
Synonyms

Glycidyl Arachidonate; (5Z,8Z,11Z,14Z)- 5,8,11,14-Eicosatetraenoic Acid Oxiranylmethyl Ester; Arachidonoyl-glycidyl Ester;

Molecular Formula

C23H36O3

Purity 95%
Storage -20°C
InChIKey ACYNJBAUKQMZDF-DOFZRALJSA-N

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