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AR-C 102222

AR-C 102222

  • CAT Number: I010866
  • CAS Number: 253771-21-0
  • Molecular Formula: C19H16F2N6O.HCl
  • Molecular Weight: 418.83
  • Purity: ≥95%
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AR-C 102222 (Cat.No:I010866) is an inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC<sub>50</sub> values are 0.037 and &#62;100 <span class=/’symbol/’>&#956;</span>M for iNOS and eNOS respectively). Exhibits antinociceptive and anti-inflammatory activity in rodent pain models.

Catalog Number I010866
CAS Number 253771-21-0
Synonyms

5-[(4/’-Amino-5/’,8/’-difluorospiro[piperidine-4,2/'(1/’H)-quinaxolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride

Molecular Formula

C19H16F2N6O.HCl

Purity 95%
Target iNOS
Solubility Soluble to 25 mM in water and to 100 mM in DMSO
Storage Store at 4℃
IUPAC Name 5-(4-amino-5,8-difluorospiro[1H-quinazoline-2,4'-piperidine]-1'-carbonyl)pyridine-2-carbonitrile;hydrochloride
InChI InChI=1S/C19H16F2N6O.ClH/c20-13-3-4-14(21)16-15(13)17(23)26-19(25-16)5-7-27(8-6-19)18(28)11-1-2-12(9-22)24-10-11;/h1-4,10,25H,5-8H2,(H2,23,26);1H
InChIKey FJFMOBYDHGJDGV-UHFFFAOYSA-N
SMILES C1CN(CCC12NC3=C(C=CC(=C3C(=N2)N)F)F)C(=O)C4=CN=C(C=C4)C#N.Cl

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