Apoptolidin

• CAT Number: M034940
• CAS Number: 194874-06-1
• Molecular Formula: C58H96O21
• Molecular Weight: 1129.4
• Purity: ≥95%
• Storage: -20°C
• InChIKey: WILMROCKORZEMQ-AIUMZUNXSA-N

Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines.The apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition; however, recent evidence suggests the existence of a secondary biological target or more complex mode of action.

Reference

Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Wender P.A. et al. Org. Lett. 2006, 8, 589.Apoptolidin: induction of apoptosis by a natural product. Daniel P.T. et al. Angew. Chem. Int. Ed. Engl. 2006, 45, 872.Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Salomon A.R. et al. Proc. Natl Acad. Sci. USA 2000, 97, 14766.Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. Kim J.W. et al. J. Antibiot. 1997, 50, 628.