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Apcin-A

Apcin-A

  • CAT Number: I016922
  • CAS Number: 1683617-62-0
  • Molecular Formula: C₁₀H₁₄Cl₃N₅O₂
  • Molecular Weight: 342.61
  • Purity: ≥95%
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Apcin-A (Cat.No:I016922), an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257).

Catalog Number I016922
CAS Number 1683617-62-0
Molecular Formula

C₁₀H₁₄Cl₃N₅O₂

Purity 95%
IUPAC Name 3-aminopropyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate
InChI InChI=1S/C10H14Cl3N5O2/c11-10(12,13)7(17-8-15-4-2-5-16-8)18-9(19)20-6-1-3-14/h2,4-5,7H,1,3,6,14H2,(H,18,19)(H,15,16,17)
InChIKey JQTSJVDIFMKETH-UHFFFAOYSA-N
SMILES C1=CN=C(N=C1)NC(C(Cl)(Cl)Cl)NC(=O)OCCCN
Reference

[1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2.

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