For research use only. Not for therapeutic Use.
AOH1160（Cat No.:I018151）is a potent small-molecule inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a key enzyme in the non-homologous end joining (NHEJ) pathway of DNA double-strand break repair. By selectively targeting DNA-PK activity, AOH1160 enhances sensitivity of cancer cells to radiotherapy and DNA-damaging chemotherapeutics. Preclinical studies highlight its potential in overcoming resistance mechanisms and improving therapeutic efficacy in oncology research. With strong activity and specificity, AOH1160 is a valuable tool for investigating DNA repair mechanisms, genomic stability, and novel strategies for targeted cancer therapy.
| CAS Number | 2089314-57-6 |
| Synonyms | N-[2-oxo-2-(2-phenoxyanilino)ethyl]naphthalene-1-carboxamide |
| Molecular Formula | C25H20N2O3 |
| Purity | ≥95% |
| IUPAC Name | N-[2-oxo-2-(2-phenoxyanilino)ethyl]naphthalene-1-carboxamide |
| InChI | InChI=1S/C25H20N2O3/c28-24(17-26-25(29)21-14-8-10-18-9-4-5-13-20(18)21)27-22-15-6-7-16-23(22)30-19-11-2-1-3-12-19/h1-16H,17H2,(H,26,29)(H,27,28) |
| InChIKey | COPRLRLXDBSLET-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)CNC(=O)C3=CC=CC4=CC=CC=C43 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
