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Antitrypanosomal agent 1

Antitrypanosomal agent 1

  • CAT Number: I015082
  • CAS Number: 75144-12-6
  • Molecular Formula: C₁₁H₁₄Cl₃NO
  • Molecular Weight: 282.59
  • Purity: ≥95%
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Antitrypanosomal agent 1 (Cat No.:I015082) is a potent and selective trypanothione reductase inhibitor with IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase with IC50 of 64.8 μM; against Trypanosoma brucei with EC50 of 1 μM. Antitrypanosomal agent 1 has antitrypanosomal activity.

Catalog Number I015082
CAS Number 75144-12-6
Molecular Formula

C₁₁H₁₄Cl₃NO

Purity 95%
Storage 2-8°C
IUPAC Name 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one;hydrochloride
InChI InChI=1S/C11H13Cl2NO.ClH/c1-14(2)6-5-11(15)8-3-4-9(12)10(13)7-8;/h3-4,7H,5-6H2,1-2H3;1H
InChIKey PRRKQCKNKRZOPV-UHFFFAOYSA-N
SMILES CN(C)CCC(=O)C1=CC(=C(C=C1)Cl)Cl.Cl
Reference

[1]. Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3.

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