For research use only. Not for therapeutic Use.
Antalarmin hydrochloride（Cat No.:R061499）is a selective, non-peptide antagonist of the corticotropin-releasing factor type 1 receptor (CRF₁), which plays a central role in stress response, anxiety, and depression through the hypothalamic-pituitary-adrenal (HPA) axis. By blocking CRF₁ receptor activation, Antalarmin reduces the release of adrenocorticotropic hormone (ACTH) and subsequent cortisol production, making it valuable in research on stress-related and neuropsychiatric disorders. It has shown promise in preclinical models for treating anxiety, depression, irritable bowel syndrome, and inflammatory conditions. Antalarmin hydrochloride is a key tool for exploring CRF₁-mediated signaling and therapeutic interventions targeting stress-related pathologies.
| CAS Number | 220953-69-5 |
| Synonyms | N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine;hydrochloride |
| Molecular Formula | C24H35ClN4 |
| Purity | ≥95% |
| IUPAC Name | N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine;hydrochloride |
| InChI | InChI=1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H |
| InChIKey | CGDGXEDXEXACKQ-UHFFFAOYSA-N |
| SMILES | CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
