Anserine-d4

• CAT Number: I045591
• CAS Number: 1201658-81-2
• Molecular Formula: C10H12D4N4O3
• Molecular Weight: 244.28
• Purity: ≥95%
• Synonyms: (2S)-2-[(3-amino-2,2,3,3-tetradeuteriopropanoyl)amino]-3-(3-methylimidazol-4-yl)propanoic acid
• InChI: InChI=1S/C10H16N4O3/c1-14-6-12-5-7(14)4-8(10(16)17)13-9(15)2-3-11/h5-6,8H,2-4,11H2,1H3,(H,13,15)(H,16,17)/t8-/m0/s1/i2D2,3D2
• InChIKey: MYYIAHXIVFADCU-XDTSEJTKSA-N
• SMILES: CN1C=NC=C1CC(C(=O)O)NC(=O)CCN

Anserine-d4 (Cat No.: I045591) is a stable isotope-labeled derivative of anserine, a naturally occurring histidine-containing dipeptide (β-alanyl-1-methyl-L-histidine) found in skeletal muscle and brain tissue. Incorporating four deuterium atoms, Anserine-d4 is primarily used as an internal standard in liquid chromatography–mass spectrometry (LC-MS/MS) for accurate quantification of anserine in biological samples. It enables precise metabolic, nutritional, and pharmacokinetic studies involving histidine dipeptides. As a labeled analog, Anserine-d4 supports research in muscle physiology, oxidative stress, and the role of bioactive peptides in human health.

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Boldyrev AA, et al. The histidine-containing dipeptides, carnosine and anserine: distribution, properties and biological significance. Adv Enzyme Regul. 1990;30:175-94.
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[3]. Jun Kaneko, et al. Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer’s-model mice. Sci Rep. 2017 Oct 3;7(1):12571.
[Content Brief]