Ansamitocin P-3

• CAT Number: I004503
• CAS Number: 66584-72-3
• Molecular Formula: C32H43ClN2O9
• Molecular Weight: 635.14
• Purity: ≥95%
• Target: Microtubule; ADCs cytotoxin
• Solubility: 10 mM in DMSO
• Storage: 3 years -20℃ powder
• IC50: 0.015 ng/ml (Antiproliferative activity for primary human endothel cells) [1]
• IUPAC Name: [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-methylpropanoate
• InChI: InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28+,31+,32+/m1/s1
• InChIKey: OPQNCARIZFLNLF-JBHFWYGFSA-N
• SMILES: CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)C)C)C)OC)(NC(=O)O2)O

Ansamitocin P-3 (Cat.No:I004503) is a potent cytotoxic ansamycin antibiotic derived from Actinosynnema pretiosum. It exerts its anti-tumor activity by inhibiting the function of the microtubules, thereby blocking cell division and inducing apoptosis. Ansamitocin P-3 has shown promising results in clinical trials against several types of cancer, including non-small cell lung cancer and pancreatic cancer.

Reference

[1]. Axel Meyer, et al. Chemoenzymatic Approaches toward Dechloroansamitocin P-3. Org. Lett., 2007, 9 (8), pp 1489-1492.
[2]. Liu Z, et al. An API LC/MS/MS quantitation method for ansamitocin P-3 (AP3) and its preclinical pharmacokinetics. J Pharm Biomed Anal. 2004 Nov 19;36(4):815-21.
[3]. Suwanborirux K, et al. Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes. Experientia. 1990 Jan 15;46(1):117-20.
[4]. Liu Z, et al. Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry. J Mass Spectrom. 2005 Mar;40(3):389-99.