Anisodamine

• CAT Number: I004088
• CAS Number: 55869-99-3
• Molecular Formula: C17H23NO4
• Molecular Weight: 305.4
• Purity: ≥95%
• Synonyms: αS-​(hydroxymethyl)​-​benzeneacetic acid, (1R,​3S,​5R,​6S)​-​6-​hydroxy-​8-​methyl-​8-​azabicyclo[3.2.1]​oct-​3-​yl ester
• Target: Adrenergic Receptor
• Solubility: 10 mM in H2O
• Storage: Store at -20°C
• IUPAC Name: [(1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate
• InChI: InChI=1S/C17H23NO4/c1-18-12-7-13(9-15(18)16(20)8-12)22-17(21)14(10-19)11-5-3-2-4-6-11/h2-6,12-16,19-20H,7-10H2,1H3
• InChIKey: WTQYWNWRJNXDEG-RBZJEDDUSA-N
• SMILES: O=C([C@H](CO)C1=CC=CC=C1)O[C@@H]2C[C@@H](N3C)[C@@H](O)C[C@@H]3C2

Anisodamine is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock, is also a naturally occurring tropane alkaloid found in some plants of the Solanaceae family.

Reference

1:Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling. Xu ZQ, Shao BZ, Ke P, Liu JG, Liu GK, Chen XW, Su DF, Liu C.Sci Rep. 2016 Nov 22;6:37709. doi: 10.1038/srep37709. PMID: 27874086 Free PMC Article2:[A case of neonatal anisodamine poisoning]. Li N, Liu X, Sun X.Zhonghua Er Ke Za Zhi. 2016 Jan;54(1):68. doi: 10.3760/cma.j.issn.0578-1310.2016.01.017. Chinese. No abstract available. PMID: 27470478 3:Cardioprotective Effect of Anisodamine Against Myocardial Ischemia Injury and its Influence on Cardiomyocytes Apoptosis. Xing K, Fu X, Jiang L, Wang Y, Li W, Gu X, Hao G, Miao Q, Ge X, Peng Y, Geng W, Bai S, Wei L, Bi X.Cell Biochem Biophys. 2015 Dec;73(3):707-16. doi: 10.1007/s12013-015-0642-4. PMID: 27259314 4:Possible role for anisodamine in organophosphate poisoning. Eisenkraft A, Falk A.Br J Pharmacol. 2016 Jun;173(11):1719-27. doi: 10.1111/bph.13486. Epub 2016 Apr 22. Review. PMID: 27010563 5:Intracoronary administration of different doses of anisodamine in primary percutaneous coronary intervention: protective effect in patients with ST-segment elevation myocardial infarction. Bai S, Fu X, Gu X, Wang Y, Li W, Fan Y, Wei L, Bi X.Coron Artery Dis. 2016 Jun;27(4):302-10. doi: 10.1097/MCA.0000000000000366. PMID: 26945186 6:[Multi-function electric ion fenestration combined with anisodamine and other drugs in the treatment of pseudocyst of auricle]. Wu Y, Yan P, Cui L.Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1561-2. Chinese. No abstract available. PMID: 26647545 7:Intracoronary administration of anisodamine and nicorandil in individuals undergoing primary percutaneous coronary intervention for acute inferior myocardial infarction: A randomized factorial trial. Chen C, Fu X, Li W, Jia X, Bai S, Geng W, Xing K.Exp Ther Med. 2015 Sep;10(3):1059-1065. Epub 2015 Jul 7. PMID: 26622439 Free PMC Article8:Effectiveness of anisodamine for the treatment of critically ill patients with septic shock (ACIdoSIS study): study protocol for randomized controlled trial. Zhang Z, Zhou J, Shang Y, Wang X, Yin R, Zhu Z, Chen W, Tian X, Yu Y, Zuo X, Chen K, Ji X, Ni H; Anisodamine Critically Ill SeptIc Shock (ACIdoSIS) study group..Ann Transl Med. 2015 Oct;3(17):246. doi: 10.3978/j.issn.2305-5839.2015.10.03. PMID: 26605292 Free PMC Article9:Simultaneous determination of scopolamine, hyoscyamine and anisodamine in in vitro growth media of selected Solanaceae hairy roots by CE method. Dziomba S, Łepek T, Jaremicz Z, Łuczkiewicz M, Prahl A, Kowalski P.J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15;1001:17-21. doi: 10.1016/j.jchromb.2015.06.029. Epub 2015 Jul 22. PMID: 26253806 10:[Effect of anisodamine on myocardial connexin 43 expression in pig after resuscitation from cardiac arrest]. Liu Y, Shen H, Wang L, Yang H, Ma L.Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Mar;27(3):209-12. doi: 10.3760/cma.j.issn.2095-4352.2015.03.010. Chinese. PMID: 25757971 Free Article