Aniracetam

  • CAT Number: A000210
  • CAS Number: 72432-10-1
  • Molecular Formula: C12H13NO3
  • Molecular Weight: 219.24
  • Purity: ≥95%
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Aniracetam (Cat. No: A000210), also known as Ampamet, is a class of brain cell metabolic drugs. It can selectively act on the central nervous system through BBB (blood-brain barrier) and activate the metabolism of brain cells. Aniracetam can be used to study brain dysfunction.

Catalog Number A000210
CAS Number 72432-10-1
Molecular Formula

C12H13NO3

Purity 95%
Target AMPAR
Solubility Soluble in DMSO > 10 mM
Storage Store at -20°C
IUPAC Name 1-(4-methoxybenzoyl)pyrrolidin-2-one
InChI 1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3
InChIKey ZXNRTKGTQJPIJK-UHFFFAOYSA-N
SMILES COC1=CC=C(C=C1)C(=O)N2CCCC2=O
Reference

1: Elston TW, Pandian A, Smith GD, Holley AJ, Gao N, Lugo JN. Aniracetam does not
alter cognitive and affective behavior in adult C57BL/6J mice. PLoS One. 2014 Aug
6;9(8):e104443. doi: 10.1371/journal.pone.0104443. eCollection 2014. PubMed PMID:
25099639; PubMed Central PMCID: PMC4123976.
<br>

2: Shao X, Li Y, Li F, Liu Y, Song Z. Subnanogram determination of aniracetam in
pharmaceutical preparations and biofluids by flow injection analysis with
chemiluminescence detection based on its enhancement of the myoglobin-luminol
reaction. J AOAC Int. 2011 Sep-Oct;94(5):1461-6. PubMed PMID: 22165010.

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3: Koliaki CC, Messini C, Tsolaki M. Clinical efficacy of aniracetam, either as
monotherapy or combined with cholinesterase inhibitors, in patients with
cognitive impairment: a comparative open study. CNS Neurosci Ther. 2012
Apr;18(4):302-12. doi: 10.1111/j.1755-5949.2010.00244.x. Epub 2011 Feb 26. PubMed
PMID: 22070796.

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4: Papandreou G, Zorpas K, Archontaki H. Development and validation of a liquid
chromatographic method for the simultaneous determination of aniracetam and its
related substances in the bulk drug and a tablet formulation. J Pharm Biomed
Anal. 2011 Nov 1;56(3):615-22. doi: 10.1016/j.jpba.2011.06.005. Epub 2011 Jun 16.
PubMed PMID: 21742456.
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5: Li Y, Hu D, Sun Y. Content determination of aniracetam in aniracetam inclusion
complex by HPLC. Artif Cells Blood Substit Immobil Biotechnol. 2009;37(3):143-5.
doi: 10.1080/10731190902908387. Epub 2009 May 1. PubMed PMID: 19412824.
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6: Pan Y, Dai T, Yang Q. [Influence of aniracetam on the learning ability, memory
ability and the expression of BCL-2 of hippocampal in vascular dementia model
rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009 May;25(2):180-1, 227.
Chinese. PubMed PMID: 21189545.

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7: Tian Y, Zhang JJ, Feng SD, Zhang ZJ, Chen Y. Pharmacokinetics and
bioequivalence study of aniracetam after single-dose administration in healthy
Chinese male volunteers. Arzneimittelforschung. 2008;58(10):497-500. doi:
10.1055/s-0031-1296547. PubMed PMID: 19025058.
<br>

8: Rial D, Takahashi RN, Morato GS. Aniracetam and DNQX affect the acquisition of
rapid tolerance to ethanol in mice. Pharmacol Biochem Behav. 2009 Mar;92(1):32-8.
doi: 10.1016/j.pbb.2008.10.006. Epub 2008 Oct 25. PubMed PMID: 18992274.

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9: Wijayawardhane N, Shonesy BC, Vaithianathan T, Pandiella N, Vaglenova J,
Breese CR, Dityatev A, Suppiramaniam V. Ameliorating effects of preadolescent
aniracetam treatment on prenatal ethanol-induced impairment in AMPA receptor
activity. Neurobiol Dis. 2008 Jan;29(1):81-91. Epub 2007 Aug 14. PubMed PMID:
17916430.
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10: Zhang J, Liang J, Tian Y, Zhang Z, Chen Y. Sensitive and selective liquid
chromatography-tandem mass spectrometry method for the quantification of
aniracetam in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2007
Oct 15;858(1-2):129-34. Epub 2007 Aug 21. PubMed PMID: 17826366.

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