Angiotensin I/II (1-6) (TFA)

• CAT Number: I044309
• Molecular Formula: C38H56F3N11O12
• Molecular Weight: 915.91
• Purity: ≥95%
• Synonyms: (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-imidazol-5-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C36H55N11O10.C2HF3O2/c1-5-19(4)29(34(55)45-26(35(56)57)14-21-16-40-17-42-21)47-32(53)25(13-20-8-10-22(48)11-9-20)44-33(54)28(18(2)3)46-31(52)24(7-6-12-41-36(38)39)43-30(51)23(37)15-27(49)50;3-2(4,5)1(6)7/h8-11,16-19,23-26,28-29,48H,5-7,12-15,37H2,1-4H3,(H,40,42)(H,43,51)(H,44,54)(H,45,55)(H,46,52)(H,47,53)(H,49,50)(H,56,57)(H4,38,39,41);(H,6,7)/t19-,23-,24-,25-,26-,28-,29-;/m0./s1
• InChIKey: NHVJMAYWVZIFSD-QRTQXXRZSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N.C(=O)(C(F)(F)F)O

Angiotensin I/II (1–6) (TFA)（Cat No.:I044309）is a synthetic hexapeptide representing the N-terminal sequence shared by both angiotensin I and II, key components of the renin-angiotensin system (RAS). This peptide fragment, typically Asp-Arg-Val-Tyr-Ile-His, plays a role in modulating vascular tone, blood pressure, and fluid balance. While less biologically active than the full-length hormones, it is used in research to study angiotensin processing, receptor binding, and enzyme-substrate interactions. The TFA (trifluoroacetate) form enhances solubility and storage stability. It is valuable in cardiovascular, renal, and metabolic disease studies exploring RAS-related pathways.