Angelicin

• CAT Number: I003915
• CAS Number: 523-50-2
• Molecular Formula: C11H6O3
• Molecular Weight: 186.2
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)
• InChIKey: XDROKJSWHURZGO-UHFFFAOYSA-N

Angelicin (CAT: I003915), also known as psoralen, is a natural furanocoumarin compound found in various plants, such as Psoralea corylifolia and Ammi majus. It exhibits phototoxic and photochemotherapeutic properties. Angelicin is commonly used in combination with ultraviolet A (UVA) radiation in a treatment known as PUVA (psoralen plus UVA therapy) for certain skin disorders, including psoriasis, vitiligo, and cutaneous T-cell lymphoma. When activated by UVA light, angelicin forms covalent crosslinks with DNA, which interferes with DNA replication and inhibits cell proliferation. This mechanism helps to reduce inflammation, promote repigmentation, and suppress abnormal cell growth.

Reference

[1]. Md. Ataur Rahman, Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SY5Y neuroblastoma cells. Molecular and Cellular Biochemistry
October 2012, Volume 369, Issue 1-2, pp 95-104

[2]. Hye-Jeong Cho, et al. Antiviral activity of angelicin against gammaherpesviruses. Antiviral Research
Volume 100, Issue 1, October 2013, Pages 75–83

[3]. Fang Liu, et al. Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. Journal of Surgical Research
Volume 185, Issue 1, November 2013, Pages 300–309