Amsacrine hydrochloride

• CAT Number: I003990
• CAS Number: 54301-15-4
• Molecular Formula: C21H20ClN3O3S
• Molecular Weight: 429.92
• Purity: ≥95%
• Target: Topoisomerase
• Solubility: DMSO:10 mg/mL; 30% Ethanol: 4 mg/mL
• Storage: Store at -20C
• IUPAC Name: N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide;hydrochloride
• InChI: InChI=1S/C21H19N3O3S.ClH/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21;/h3-13,24H,1-2H3,(H,22,23);1H
• InChIKey: WDISRLXRMMTXEV-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42.Cl

Amsacrine hydrochloride (Cat No.: I003990), also known as m-AMSA hydrochloride; acridinyl anisidide hydrochloride, is a tumor cell DNA intercalator and can also inhibit topoisomerase II. Amsacrine hydrochloride is mainly used as an antineoplastic drug. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Liu WH, et al. Amsacrine suppresses matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia cells. J Cell Physiol. 2013 Oct 7.

[2]. Thomas D, et al. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94.

[3]. Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33(6):426-33.

[4]. Kao-Shan CS, et al. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat Rep. 1984 Jul-Aug;68(7-8):989-97.