Amrinone

• CAT Number: R009222
• CAS Number: 60719-84-8
• Molecular Formula: C10H9N3O
• Molecular Weight: 187.202
• Purity: ≥95%
• Target: Pyridine Phosphodiesterase 3 Inhibitor
• Storage: -20°C
• IUPAC Name: 3-amino-5-pyridin-4-yl-1H-pyridin-2-one
• InChI: InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
• InChIKey: RNLQIBCLLYYYFJ-UHFFFAOYSA-N
• SMILES: C1=CN=CC=C1C2=CNC(=O)C(=C2)N

Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). The positive inotropic effect of amrinone is mediated by the selective enhancement of high gain CICR which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways. Amrinone increases cardiac contractility as a vasodilator. It acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme.

Reference

1:Amrinone, forerunner of novel cardiotonic agents, caused paradigm shift of heart failure pharmacotherapy. Endoh M.Circ Res. 2013 Aug 2;113(4):358-61. doi: 10.1161/CIRCRESAHA.113.301689. No abstract available. PMID: 23908328 Free Article2:Retraction note to: Amrinone improves contractility of fatigued diaphragm in dogs. Can J Anaesth 1995; 42: 80-6,DOI 10.1007/BF03010577. Miller DR.Can J Anaesth. 2012 Dec;59(12):1176. doi: 10.1007/s12630-012-9838-x. English, French. PMID: 23184630 3:Phosphodiesterase-III Inhibitors Amrinone and Milrinone on Epilepsy and Cardiovascular Activities. Asif M.N Am J Med Sci. 2012 Oct;4(10):499-502. doi: 10.4103/1947-2714.102001. No abstract available. PMID: 23112975 Free PMC Article4:Effects of amrinone in an experimental model of hepatic ischemia-reperfusion injury. Kucuk C, Akcan A, Akyýldýz H, Akgun H, Muhtaroglu S, Sozuer E.J Surg Res. 2009 Jan;151(1):74-9. doi: 10.1016/j.jss.2008.02.008. Epub 2008 Mar 13. PMID: 18468627 5:Comparison of the initial hospitalization costs between the patients treated with dobutamine and the patients treated with amrinone for acute decompensated heart failure in a Japanese institute. Komamura K, Matsuo H, Sasaki T.Value Health. 2008 Mar;11 Suppl 1:S39-42. doi: 10.1111/j.1524-4733.2008.00365.x. PMID: 18387066 Free Article6:[Protection of amrinone against lung injury induced by ischemia/reperfusion in rats]. Gong SG, Liu JM.Zhongguo Dang Dai Er Ke Za Zhi. 2007 Jun;9(3):233-6. Chinese. PMID: 17582263 7:Protective effects of different antioxidants and amrinone on vancomycin-induced nephrotoxicity. Celik I, Cihangiroglu M, Ilhan N, Akpolat N, Akbulut HH.Basic Clin Pharmacol Toxicol. 2005 Nov;97(5):325-32. PMID: 16236146 Free Article8:Effects of inotropic drugs on mechanical function and oxygen balance in postischemic canine myocardium: comparison of dobutamine, epinephrine, amrinone, and calcium chloride. Yoo KY, Kim H, Jeong CW, Park HC, Bae HB, Lee J.J Korean Med Sci. 2005 Oct;20(5):732-9. PMID: 16224144 Free PMC Article9:The effect of amrinone on liver regeneration in experimental hepatic resection model. Akcan A, Kucuk C, Ok E, Canoz O, Muhtaroglu S, Yilmaz N, Yilmaz Z.J Surg Res. 2006 Jan;130(1):66-72. Epub 2005 Sep 8. PMID: 16154150 10:Effect of amrinone on mucosal permeability in experimental intestinal ischaemia/reperfusion injury. Ekingen G, Sönmez K, Ozen O, Demirogullari B, Karabulut R, Türkyilmaz Z, Yenidünya S, Ayayvaci S, Basaklar AC, Kale N.ANZ J Surg. 2005 Jul;75(7):608-13. PMID: 15972057