Amodiaquine hydrochloride

• CAT Number: I022094
• CAS Number: 69-44-3
• Molecular Formula: C20H24Cl3N3O
• Molecular Weight: 428.78
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Room Temperature
• IUPAC Name: Amodiaquine hydrochloride
• InChI: InChI=1S/C20H22ClN3O.2ClH/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);2*1H
• InChIKey: ROEBJVHPINPMKL-UHFFFAOYSA-N
• SMILES: CCN(CC1=CC(NC2=CC=NC3=CC(Cl)=CC=C23)=CC=C1O)CC.[H]Cl.[H]Cl

Amodiaquine dihydrochloride（Cat No.:I022094）, a 4-aminoquinoline antimalarial agent, serves as a potent inhibitor of histamine N-methyltransferase (HNMT) with a Ki value of 18.6 nM. By inhibiting HNMT, it modulates histamine levels in the body. Additionally, amodiaquine dihydrochloride acts as a Nurr1 agonist, binding to the ligand-binding domain of Nurr1 with an EC50 of approximately 20 μM. Nurr1 is a transcription factor involved in the regulation of genes associated with dopamine synthesis. The multifaceted properties of amodiaquine dihydrochloride suggest potential applications in the treatment of malaria, histamine-related disorders, and neurodegenerative diseases.

Reference

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