AMMONIUM TETRATHIOMOLYBDATE

  • CAT Number: M055180
  • CAS Number: 15060-55-6
  • Molecular Formula: H10MoN2S4
  • Molecular Weight: 262.284
  • Purity: ≥95%
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Tiomolibdate diammonium, also known as Ammonium tetrathiomolybdate, is a SOD1 inhibitor with potential antiangiogenic and antitumor activities. ammonium Tiomolibdate diammonium has been found to deplete systemic copper reserves through an unknown mechanism. This agent has been shown to inhibit the activities of cuproenzymes, including superoxide dismutase 1 (SOD1) and cytochrome c oxidase (COX), which may contribute to its antiangiogenic and antitumor effects.

Catalog Number M055180
CAS Number 15060-55-6
Molecular Formula

H10MoN2S4

Purity 95%
Target SOD1 inhibitor
Storage Store at -20C
IUPAC Name diazanium;bis(sulfanylidene)molybdenum;sulfanide
InChI InChI=1S/Mo.2H3N.2H2S.2S/h;2*1H3;2*1H2;;
InChIKey ZKKLPDLKUGTPME-UHFFFAOYSA-N
SMILES [NH4+].[NH4+].[SH-].[SH-].S=[Mo]=S
Reference

</br>1:Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin. Chisholm CL, Wang H, Wong AH, Vazquez-Ortiz G, Chen W, Xu X, Deng CX.Oncotarget. 2016 Dec 20;7(51):84439-84452. doi: 10.18632/oncotarget.12992. PMID: 27806319 Free PMC Article</br>2:Ammonium tetrathiomolybdate as a water-soluble and slow-release hydrogen sulfide donor. Xu S, Yang CT, Meng FH, Pacheco A, Chen L, Xian M.Bioorg Med Chem Lett. 2016 Mar 15;26(6):1585-8. doi: 10.1016/j.bmcl.2016.02.005. Epub 2016 Feb 4. PMID: 26898812 Free PMC Article</br>3:Pharmacologic evaluation of ammonium tetrathiomolybdate after intravenous and oral administration to healthy dogs. Chan CM, Langlois DK, Buchweitz JP, Lehner AF, Olivier NB, Herdt TH, Bailie MB, Schall WD.Am J Vet Res. 2015 May;76(5):445-53. doi: 10.2460/ajvr.76.5.445. PMID: 25909377 </br>4:Ammonium tetrathiomolybdate: a versatile catalyst for hydrogen evolution reaction from water under ambient and hostile conditions. Chatterjee S, Sengupta K, Dey S, Dey A.Inorg Chem. 2013 Dec 16;52(24):14168-77. doi: 10.1021/ic402056k. Epub 2013 Nov 21. PMID: 24261567 </br>5:Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis. Tokuda E, Ono S, Ishige K, Watanabe S, Okawa E, Ito Y, Suzuki T.Exp Neurol. 2008 Sep;213(1):122-8. doi: 10.1016/j.expneurol.2008.05.011. Epub 2008 May 23. PMID: 18617166 </br>6:Effects of ammonium tetrathiomolybdate, an oncolytic/angiolytic drug on the viability and proliferation of endothelial and tumor cells. Carpenter A, Rassam A, Jennings MH, Robinson-Jackson S, Alexander JS, Erkuran-Yilmaz C.Inflamm Res. 2007 Dec;56(12):515-9. doi: 10.1007/s00011-007-7025-2. PMID: 18210236 </br>7:Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease. Brewer GJ, Askari F, Lorincz MT, Carlson M, Schilsky M, Kluin KJ, Hedera P, Moretti P, Fink JK, Tankanow R, Dick RB, Sitterly J.Arch Neurol. 2006 Apr;63(4):521-7. PMID: 16606763 </br>8:Inhibition kinetics of mushroom tyrosinase by copper-chelating ammonium tetrathiomolybdate. Park KH, Park YD, Lee JR, Hahn HS, Lee SJ, Bae CD, Yang JM, Kim DE, Hahn MJ.Biochim Biophys Acta. 2005 Oct 30;1726(1):115-20. Epub 2005 Jul 5. PMID: 16039066 </br>9:Molybdenum-associated pituitary endocrinopathy in sheep treated with ammonium tetrathiomolybdate. Haywood S, Dincer Z, Jasani B, Loughran MJ.J Comp Pathol. 2004 Jan;130(1):21-31. PMID: 14693121 </br>10:Expression of lysyl oxidase and effect of copper chloride and ammonium tetrathiomolybdate on bovine ovarian follicle granulosa cells cultured in serum-free media. Kendall NR, Marsters P, Scaramuzzi RJ, Campbell BK.Reproduction. 2003 May;125(5):657-65. PMID: 12713428 Free Article

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