Amitriptyline

• CAT Number: I000473
• CAS Number: 50-48-6
• Molecular Formula: C20H23N
• Molecular Weight: 277.411
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: Store at 4°C
• IUPAC Name: N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
• InChI: InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
• InChIKey: KRMDCWKBEZIMAB-UHFFFAOYSA-N
• SMILES: CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31

Amitriptyline (CAT: I000473) is a tricyclic antidepressant medication that is primarily used in the treatment of depression and various other mood disorders. It works by increasing the levels of certain neurotransmitters, such as serotonin and norepinephrine, in the brain, which helps to improve mood and alleviate symptoms of depression. Amitriptyline also has analgesic properties and is sometimes prescribed for the management of chronic pain conditions, such as neuropathic pain and fibromyalgia. Additionally, it can be used off-label to treat other conditions like insomnia and migraines.

Overview of Clinical Research

Amitriptyline has been granted for its orphan drug status in Erythromelalgia. AlgoTherapeutix intends to launch amitriptyline topical for Neuropathic pain in 2025.

Reference

1: Lawson K. A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. Biomedicines. 2017 May 17;5(2). pii: E24. doi: 10.3390/biomedicines5020024. Review. PubMed PMID: 28536367; PubMed Central PMCID: PMC5489810.
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