Amitraz

• CAT Number: I003188
• CAS Number: 33089-61-1
• Molecular Formula: C19H23N3
• Molecular Weight: 293.41
• Purity: ≥95%
• Target: MAO inhibitorMedKoo
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• IUPAC Name: N'-(2,4-dimethylphenyl)-N-[(2,4-dimethylphenyl)iminomethyl]-N-methylmethanimidamide
• InChI: InChI=1S/C30H27BrN4O2/c31-24-10-8-22(9-11-24)17-35-21-32-16-25(35)18-33-19-28(27-7-3-5-23-4-1-2-6-26(23)27)29(20-33)30(36)34-12-14-37-15-13-34/h1-11,16,19-21H,12-15,17-18H2
• InChIKey: GUUIRIMAQGOLHT-UHFFFAOYSA-N
• SMILES: O=C(N1CCOCC1)C2=CN(C=C2C3=C4C=CC=CC4=CC=C3)CC5=CN=CN5CC6=CC=C(C=C6)Br

Amitraz (Cat.No:I003188) is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

Reference

1:Amitraz changes NE, DA and 5-HT biosynthesis and metabolism mediated by alterations in estradiol content in CNS of male rats. Del Pino J, Moyano P, Ruiz M, Anadón MJ, Díaz MJ, García JM, Labajo-González E, Frejo MT.Chemosphere. 2017 Aug;181:518-529. doi: 10.1016/j.chemosphere.2017.04.113. Epub 2017 Apr 26. PMID: 28463726 2:The current status of resistance to alpha-cypermethrin, ivermectin, and amitraz of the cattle tick (Rhipicephalus microplus) in Ecuador. Rodríguez-Hidalgo R, Pérez-Otáñez X, Garcés-Carrera S, Vanwambeke SO, Madder M, Benítez-Ortiz W.PLoS One. 2017 Apr 7;12(4):e0174652. doi: 10.1371/journal.pone.0174652. eCollection 2017. PMID: 28388639 Free PMC Article3:Simultaneous determination of amitraz, chlordimeform, formetanate and their main metabolites in human urine by high performance liquid chromatography-tandem mass spectrometry. Gao X, Tan Y, Guo H.J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 1;1052:27-33. doi: 10.1016/j.jchromb.2017.03.004. Epub 2017 Mar 11. PMID: 28346886 4:Detection of amitraz and malathion resistance in field populations of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) in Jammu region of India. Dutta S, Godara R, Katoch R, Yadav A, Katoch M, Singh NK.Exp Appl Acarol. 2017 Mar;71(3):291-301. doi: 10.1007/s10493-017-0111-4. Epub 2017 Mar 1. PMID: 28251410 5:The effects of sub-chronic administration of sub-lethal doses of amitraz/xylene on selected reproductive parameters of male Wistar rats. Omoja VU, Anika SM, Asuzu IU.Iran J Vet Res. 2016 Fall;17(4):277-280. PMID: 28224014 Free PMC Article6:Amitraz, an underrecognized poison: A systematic review. Dhooria S, Agarwal R.Indian J Med Res. 2016 Sep;144(3):348-358. doi: 10.4103/0971-5916.198723. Review. PMID: 28139533 Free PMC Article7:Amitraz poisoning: A case report of an unusual pesticide poisoning in Sri Lanka and literature review. Herath HM, Pahalagamage SP, Yogendranathan N, Wijayabandara MD, Kulatunga A.BMC Pharmacol Toxicol. 2017 Jan 23;18(1):6. doi: 10.1186/s40360-016-0114-5. PMID: 28110639 Free PMC Article8:Acute Exposure to Worst-Case Concentrations of Amitraz Does Not Affect Honey Bee Learning, Short-Term Memory, or Hemolymph Octopamine Levels. Rix RR, Christopher Cutler G.J Econ Entomol. 2017 Feb 1;110(1):127-132. doi: 10.1093/jee/tow250. PMID: 28028168 9:First report of amitraz and cypermethrin resistance in Rhipicephalus sanguineus sensu lato infesting dogs in Mexico. Rodriguez-Vivas RI, Ojeda-Chi MM, Trinidad-Martinez I, Bolio-González ME.Med Vet Entomol. 2017 Mar;31(1):72-77. doi: 10.1111/mve.12207. Epub 2016 Nov 11. PMID: 27859488 10:Amitraz poisoning: an unusual cause of respiratory and peripheral circulatory failure. Agrawal I, Ahmad S, Kumar M, Akram M.Trop Doct. 2016 Nov 8. pii: 0049475516677159. [Epub ahead of print] PMID: 27827799