Amiodarone

• CAT Number: I002490
• CAS Number: 1951-25-3
• Molecular Formula: C25H29I2NO3
• Molecular Weight: 645.31
• Purity: ≥95%
• Target: Potassium Channel
• Solubility: 10 mM in DMSO
• Storage: 3 years -20℃ powder
• IUPAC Name: (2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone
• InChI: InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
• InChIKey: IYIKLHRQXLHMJQ-UHFFFAOYSA-N
• SMILES: CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I

Amiodarone (Cat.No:I002490) is an antiarrhythmic medication used to treat irregular heartbeats, such as ventricular tachycardia and ventricular fibrillation. It works by slowing down the electrical impulses in the heart, which helps to restore normal heart rhythm. It is administered orally or intravenously and can have serious side effects such as lung toxicity, liver damage, and thyroid dysfunction.

Reference

1:Topical amiodarone: To be or not to be effective? Feng J.J Thorac Cardiovasc Surg. 2017 Apr 23. pii: S0022-5223(17)30847-4. doi: 10.1016/j.jtcvs.2017.04.028. [Epub ahead of print] No abstract available. PMID: 28502617 2:Antiarrhythmic effects of ranolazine used both alone for prevention of atrial fibrillation and as an add-on to intravenous amiodarone for its pharmacological cardioversion: a meta-analysis. DE Vecchis R, Ariano C, Giasi A, Cioppa C.Minerva Cardioangiol. 2017 May 10. doi: 10.23736/S0026-4725.17.04349-3. [Epub ahead of print] PMID: 28497941 3:Amiodarone-Induced Third Degree Atrioventricular Block and Extreme QT Prolongation Generating Torsade Des Pointes in Paroxysmal Atrial Fibrillation. Sequeira OR, Aquino NJ, Gómez NB, García LB, Cáceres C, Lovera OA, Centurión OA.J Atr Fibrillation. 2016 Oct 31;9(3):1502. doi: 10.4022/jafib.1502. eCollection 2016 Oct-Nov. PMID: 28496937 Free PMC Article4:Topical amiodarone during cardiac surgery: Does epicardial application of amiodarone prevent postoperative atrial fibrillation? Greenstein D, Beau J, Gottlieb G, Teller D, Kulik A.J Thorac Cardiovasc Surg. 2017 Apr 13. pii: S0022-5223(17)30700-6. doi: 10.1016/j.jtcvs.2017.04.013. [Epub ahead of print] PMID: 28495063 5:Acute amiodarone toxicity causing respiratory failure. Kaya SB, Deger S, Hacievliyagil SS, Aytemur ZA.Rev Assoc Med Bras (1992). 2017 Mar;63(3):210-212. doi: 10.1590/1806-9282.63.03.210. PMID: 28489123 Free Article6:Concomitant Treatment with Ibrutinib and Amiodarone Causing Reversible Heart Failure Syndrome. Wasserstrum Y, Raanani P, Kornowski R, Iakobishvili Z.Isr Med Assoc J. 2016 Jul;18(7):433-434. No abstract available. PMID: 28471569 Free Article7:Amiodarone-induced thyroid dysfunction and a perturbed N-desethyl-amiodarone to amiodarone ratio: could a drug-induced toxicity be regulating exposure to the offending agent? Rowland A, Rowland A, Sorich MJ, Mangoni AA.Eur J Clin Pharmacol. 2017 May 3. doi: 10.1007/s00228-017-2261-z. [Epub ahead of print] No abstract available. PMID: 28470396 8:Propafenone for supraventricular arrhythmias in septic shock-Comparison to amiodarone and metoprolol. Balik M, Kolnikova I, Maly M, Waldauf P, Tavazzi G, Kristof J.J Crit Care. 2017 Apr 26;41:16-23. doi: 10.1016/j.jcrc.2017.04.027. [Epub ahead of print] PMID: 28463737 9:Takotsubo cardiomyopathy in amiodarone-induced hyperthyroidism. Capel I, Tasa-Vinyals E, Cano-Palomares A, Bergés-Raso I, Albert L, Rigla M, Caixàs A.Endocrinol Diabetes Metab Case Rep. 2017 Feb 15;2017. pii: 16-0116. doi: 10.1530/EDM-16-0116. eCollection 2017. PMID: 28458899 Free PMC Article10:Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits. Yamagiwa Y, Haranosono Y, Nemoto S, Atsumi I, Kurata M, Kito G, Hatakeyama H, Koizumi H, Sakaki H.J Toxicol Pathol. 2017 Apr;30(2):135-143. doi: 10.1293/tox.2016-0003. Epub 2016 Nov 27. PMID: 28458451 Free PMC Article