Amiloride Hydrochloride Dihydrate

• CAT Number: A000858
• CAS Number: 17440-83-4
• Molecular Formula: C6H13Cl2N7O3
• Molecular Weight: 302.12
• Purity: ≥95%
• Target: Sodium Channel
• Solubility: >14.1mg/mL in DMSO
• Storage: -20°C
• InChI: InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
• InChIKey: LTKVFMLMEYCWMK-UHFFFAOYSA-N
• SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl

Amiloride is a potassium-sparing diuretic, first approved for use in 1967 (then known as MK 870), used in the management of hypertension and congestive heart failure. Amiloride works by directly blocking the epithelial sodium channel (ENaC) thereby inhibiting sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts in the kidneys (this mechanism is the same for triamterene). This promotes the loss of sodium and water from the body, but without depleting potassium.

Reference

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