AMG-176

• CAT Number: I002049
• CAS Number: 1883727-34-1
• Molecular Formula: C33H41ClN2O5S
• Molecular Weight: 613.21
• Purity: ≥95%
• Target: MCL1 inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months).
• InChI: InChI=1S/C33H41ClN2O5S/c1-21-6-4-8-30(40-3)27-12-9-25(27)18-36-19-33(15-5-7-23-16-26(34)11-13-28(23)33)20-41-31-14-10-24(17-29(31)36)32(37)35-42(38,39)22(21)2/h4,8,10-11,13-14,16-17,21-22,25,27,30H,5-7,9,12,15,18-20H2,1-3H3,(H,35,37)/b8-4+/t21-,22+,25-,27
• InChIKey: JQNINBDKGLWYMU-GEAQBIRJSA-N
• SMILES: O=C(N1)C2=CC(N(C[C@H]3[C@@H](CC3)[C@@H](OC)/C=C/C[C@H](C)[C@@H](C)S1(=O)=O)C4)=C(C=C2)OC[C@@]54CCCC6=CC(Cl)=CC=C65

AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.