Amentoflavone

• CAT Number: I002070
• CAS Number: 1617-53-4
• Molecular Formula: C30H18O10
• Molecular Weight: 538.5
• Purity: ≥95%
• Solubility: DMSO: ≥ 34 mg/mL
• Storage: 2-8°C
• IUPAC Name: 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
• InChI: InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
• InChIKey: YUSWMAULDXZHPY-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O

Amentoflavone（Cat No.:I002070） is a naturally occurring biflavone compound that possesses various biological properties. It exhibits anti-inflammatory activity by modulating inflammatory pathways and reducing the production of inflammatory mediators. Amentoflavone also displays potent antioxidative effects, protecting cells from oxidative stress and damage. Additionally, it shows neuroprotective properties by promoting neuronal survival and preventing neurodegeneration. The diverse range of biological activities exhibited by amentoflavone makes it a valuable compound for potential therapeutic applications in inflammation-related disorders, oxidative stress-related conditions, and neurodegenerative diseases.

Reference

1:Simultaneous quantification and semi-quantification of Amentoflavone and its metabolites in human intestinal bacteria by liquid chromatography Orbitrap high resolution mass spectrometry. Qian Y, Jiang S, Zhu Z, Wang Q, Su S, Tao J, Duan JA.Biomed Chromatogr. 2017 Apr 20. doi: 10.1002/bmc.3990. [Epub ahead of print] PMID: 28427113 2:AKR1B10-inhibitory Selaginella tamariscina extract and amentoflavone decrease the growth of A549 human lung cancer cells in vitro and in vivo. Jung YJ, Lee EH, Lee CG, Rhee KJ, Jung WS, Choi Y, Pan CH, Kang K.J Ethnopharmacol. 2017 Apr 18;202:78-84. doi: 10.1016/j.jep.2017.03.010. Epub 2017 Mar 9. PMID: 28286104 3:A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid. Yu S, Yan H, Zhang L, Shan M, Chen P, Ding A, Li SF.Molecules. 2017 Feb 16;22(2). pii: E299. doi: 10.3390/molecules22020299. Review. PMID: 28212342 Free Article4:Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson/’s disease model mice through PI3K/Akt and ERK signaling pathways. Cao Q, Qin L, Huang F, Wang X, Yang L, Shi H, Wu H, Zhang B, Chen Z, Wu X.Toxicol Appl Pharmacol. 2017 Mar 15;319:80-90. doi: 10.1016/j.taap.2017.01.019. Epub 2017 Feb 7. PMID: 28185818 5:Anticytotoxin Effects of Amentoflavone to Pneumolysin. Zhao X, Liu B, Liu S, Wang L, Wang J.Biol Pharm Bull. 2017;40(1):61-67. doi: 10.1248/bpb.b16-00598. PMID: 28049950 Free Article6:Modulatory effect of standardised amentoflavone isolated from Juniperus communis L. agianst Freund/’s adjuvant induced arthritis in rats (histopathological and X Ray anaysis). Bais S, Abrol N, Prashar Y, Kumari R.Biomed Pharmacother. 2017 Feb;86:381-392. doi: 10.1016/j.biopha.2016.12.027. Epub 2016 Dec 21. PMID: 28012393 7:Amentoflavone protects against high fat-induced metabolic dysfunction: Possible role of the regulation of adipogenic differentiation. Chen G, Han Y, He W, Liang F.Int J Mol Med. 2016 Dec;38(6):1759-1767. doi: 10.3892/ijmm.2016.2772. Epub 2016 Oct 14. PMID: 27748827 Free PMC Article8:Amentoflavone prevents sepsis-associated acute lung injury through Nrf2-GCLc-mediated upregulation of glutathione. Zong Y, Zhang H.Acta Biochim Pol. 2017;64(1):93-98. doi: 10.18388/abp.2016_1296. Epub 2016 Oct 8. PMID: 27718499 Free Article9:Cellular Metabolomics Revealed the Cytoprotection of Amentoflavone, a Natural Compound, in Lipopolysaccharide-Induced Injury of Human Umbilical Vein Endothelial Cells. Yao W, Li H, Liu Q, Gao Y, Dai J, Bao B, Zhang L, Ding A.Int J Mol Sci. 2016 Sep 9;17(9). pii: E1514. doi: 10.3390/ijms17091514. PMID: 27618027 Free PMC Article10:The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells. Zheng X, Ke Y, Feng A, Yuan P, Zhou J, Yu Y, Wang X, Feng W.Molecules. 2016 May 13;21(5). pii: E624. doi: 10.3390/molecules21050624. PMID: 27187341 Free Article