Amantadine

  • CAT Number: I001948
  • CAS Number: 768-94-5
  • Molecular Formula: C10H17N
  • Molecular Weight: 151.25
  • Purity: ≥95%
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Amantadine (Cat No.:I001948) is a medication primarily used to treat and prevent influenza A virus infections. It works by inhibiting the viral replication process, specifically the uncoating of the influenza A virus. Additionally, Amantadine is prescribed for the management of Parkinson’s disease and drug-induced extrapyramidal symptoms. It increases dopamine release and blocks its reuptake, providing antiparkinsonian effects. Amantadine may also exhibit anticholinergic properties.

Catalog Number I001948
CAS Number 768-94-5
Molecular Formula

C10H17N

Purity 95%
Solubility Soluble in DMSO, not in water
Storage Room temperature
IUPAC Name adamantan-1-amine
InChI InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
InChIKey DKNWSYNQZKUICI-UHFFFAOYSA-N
SMILES C1C2CC3CC1CC(C2)(C3)N
Reference

</br>1:The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status. Fryml LD, Williams KR, Pelic CG, Fox J, Sahlem G, Robert S, Revuelta GJ, Short EB.J Psychiatr Pract. 2017 May;23(3):191-199. doi: 10.1097/PRA.0000000000000237. PMID: 28492457 </br>2:Development of a competitive immunochromatographic assay for the sensitive detection of amantadine in chicken muscle. Wu S, Zhu F, Hu L, Xia J, Xu G, Liu D, Guo Q, Luo K, Lai W.Food Chem. 2017 Oct 1;232:770-776. doi: 10.1016/j.foodchem.2017.04.058. Epub 2017 Apr 12. PMID: 28490139 </br>3:Molecular analysis of amantadine-resistant influenza A (H1N1 pdm09) virus isolated from slum dwellers of Dhaka, Bangladesh. Rahman M, Hoque SA, Islam MA, Rahman SR.Virus Genes. 2017 Jun;53(3):377-385. doi: 10.1007/s11262-017-1447-x. Epub 2017 Apr 11. PMID: 28401407 </br>4:Amantadine for Antipsychotic-Related Weight Gain: Meta-Analysis of Randomized Placebo-Controlled Trials. Zheng W, Wang S, Ungvari GS, Ng CH, Yang XH, Gu YH, Li M, Xiang YQ, Xiang YT.J Clin Psychopharmacol. 2017 Jun;37(3):341-346. doi: 10.1097/JCP.0000000000000598. PMID: 28383359 </br>5:Dispersive micro solid phase extraction of amantadine, rimantadine and memantine in chicken muscle with magnetic cation exchange polymer. Chen D, Miao H, Zhao Y, Wu Y.J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Apr 15;1051:92-96. doi: 10.1016/j.jchromb.2017.03.005. Epub 2017 Mar 10. PMID: 28334651 </br>6:Study on the abuse of amantadine in tissues of broiler chickens by HPLC-MS/MS. You X, Yang S, Zhao J, Zhang Y, Zhao L, Cheng Y, Hou C, Xu Z.J Vet Pharmacol Ther. 2017 Jan 30. doi: 10.1111/jvp.12388. [Epub ahead of print] PMID: 28133761 </br>7:Simultaneous determination of amantadine, rimantadine, and memantine in processed products, chicken tissues, and eggs by liquid chromatography with tandem mass spectrometry. Tsuruoka Y, Nakajima T, Kanda M, Hayashi H, Matsushima Y, Yoshikawa S, Nagata M, Koike H, Nagano C, Sekimura K, Hashimoto T, Takano I, Shindo T.J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 15;1044-1045:142-148. doi: 10.1016/j.jchromb.2017.01.014. Epub 2017 Jan 11. PMID: 28107701 </br>8:Binding and Proton Blockage by Amantadine Variants of the Influenza M2<sub>WT</sub> and M2<sub>S31N</sub> Explained. Tzitzoglaki C, Wright A, Freudenberger K, Hoffmann A, Tietjen I, Stylianakis I, Kolarov F, Fedida D, Schmidtke M, Gauglitz G, Cross TA, Kolocouris A.J Med Chem. 2017 Mar 9;60(5):1716-1733. doi: 10.1021/acs.jmedchem.6b01115. Epub 2017 Feb 15. PMID: 28107633 </br>9:A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. Nolte E, Wach S, Silva IT, Lukat S, Ekici AB, Munkert J, Müller-Uri F, Kreis W, Oliveira Simões CM, Vera J, Wullich B, Taubert H, Lai X.Oncotarget. 2017 Feb 14;8(7):11676-11691. doi: 10.18632/oncotarget.14644. PMID: 28099931 Free PMC Article</br>10:An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Hu Y, Musharrafieh R, Ma C, Zhang J, Smee DF, DeGrado WF, Wang J.Antiviral Res. 2017 Apr;140:45-54. doi: 10.1016/j.antiviral.2017.01.006. Epub 2017 Jan 10. PMID: 28087313

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