AM-5308

• CAT Number: I044028
• CAS Number: 2410796-89-1
• Molecular Formula: C26H35N5O5S
• Molecular Weight: 529.65
• Purity: ≥95%
• Synonyms: 2-(6-azaspiro[2.5]octan-6-yl)-4-(2-hydroxyethylsulfonylamino)-N-[6-[(2R)-2-methylmorpholin-4-yl]pyridin-2-yl]benzamide
• InChI: InChI=1S/C26H35N5O5S/c1-19-18-31(13-15-36-19)24-4-2-3-23(27-24)28-25(33)21-6-5-20(29-37(34,35)16-14-32)17-22(21)30-11-9-26(7-8-26)10-12-30/h2-6,17,19,29,32H,7-16,18H2,1H3,(H,27,28,33)/t19-/m1/s1
• InChIKey: IUDCFCQNVQWCCI-LJQANCHMSA-N
• SMILES: C[C@@H]1CN(CCO1)C2=CC=CC(=N2)NC(=O)C3=C(C=C(C=C3)NS(=O)(=O)CCO)N4CCC5(CC5)CC4

AM-5308（Cat No.:I044028）is a selective and potent antagonist of the chemokine receptor CCR5, a G protein-coupled receptor implicated in immune cell trafficking, inflammation, and HIV entry into host cells. By blocking CCR5, AM-5308 inhibits chemokine-mediated signaling pathways and reduces recruitment of immune cells to sites of inflammation. This makes it a valuable research tool in studies of HIV infection, autoimmune disorders, and cancer immunotherapy. Its high specificity and bioavailability support investigations into CCR5’s role in disease progression, particularly in conditions where immune modulation and cell migration are critical therapeutic targets.