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AM 281

AM 281

  • CAT Number: R016034
  • CAS Number: 202463-68-1
  • Molecular Formula: C21H19Cl2IN4O2
  • Molecular Weight: 557.213
  • Purity: ≥95%
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AM281 is a synthetic cannabinoid CB1 receptor antagonist.

Catalog Number R016034
CAS Number 202463-68-1
Molecular Formula

C21H19Cl2IN4O2

Purity 95%
Target Cannabinoid Receptor
Solubility Soluble in DMSO > 10 mM
Storage Desiccate at +4C
IUPAC Name 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide
InChI InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
InChIKey AJFFBPZYXRNAIC-UHFFFAOYSA-N
SMILES CC1=C(N(N=C1C(=O)NN2CCOCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I
Reference

</br>1:Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats. Kadoi Y, Hinohara H, Kunimoto F, Saito S, Goto F.Crit Care Med. 2005 Nov;33(11):2629-36. PMID: 16276190 </br>2:Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices. Gifford AN, Tang Y, Gatley SJ, Volkow ND, Lan R, Makriyannis A.Neurosci Lett. 1997 Nov 28;238(1-2):84-6. PMID: 9464661

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