Aloin

• CAT Number: I001592
• CAS Number: 1415-73-2
• Molecular Formula: C21H22O9
• Molecular Weight: 418.4
• Purity: ≥95%
• Target: tyrosinase
• Solubility: DMSO: 27 mg/mL
• Storage: 2-8°C
• IUPAC Name: (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
• InChI: InChI=1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14+,17-,19+,20-,21+/m1/s1
• InChIKey: AFHJQYHRLPMKHU-OSYMLPPYSA-N
• SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2C4C(C(C(C(O4)CO)O)O)O)C=C(C=C3O)CO

Aloin, a natural anthracycline extracted from aloe vera, is a tyrosinase inhibitor with an inhibition rate of 2mM. Aloin acts on HeLaS3 cells with an IC50 of 97 μM. Recent studies have shown that aloin is an antineoplastic drug that enhances melanin production and transglutaminase activity.

Reference

[1]. Pan Q, et al. Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. Cancer Cell Int. 2013 Jul 12;13(1):69.

[2]. Tabolacci C, et al. Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. Amino Acids. 2013 Jan;44(1):293-300.

[3]. Cui Y, et al. Aloin protects against chronic alcoholic liver injury via attenuating lipid accumulation, oxidative stress and inflammation in mice. Arch Pharm Res. 2014 Dec;37(12):1624-33.