Aloe emodin

• CAT Number: I003695
• CAS Number: 481-72-1
• Molecular Formula: C15H10O5
• Molecular Weight: 270.2
• Purity: ≥95%
• Solubility: DMSO: 50 mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
• InChI: InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
• InChIKey: YDQWDHRMZQUTBA-UHFFFAOYSA-N
• SMILES: O=C1C2=CC(CO)=CC(O)=C2C(C3=C1C=CC=C3O)=O

Aloe emodin (CAT: I003695) is a natural anthraquinone compound found in various species of plants, including Aloe vera. It possesses a range of pharmacological activities, including anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. Aloe emodin has been studied for its potential therapeutic applications in various diseases, such as cancer, inflammation-related disorders, diabetes, and microbial infections. It exhibits anticancer effects by inducing apoptosis, inhibiting cell proliferation, and interfering with various signaling pathways involved in tumor growth and metastasis. Additionally, aloe emodin has shown promising results in preclinical studies for its anti-inflammatory effects and its ability to modulate oxidative stress.

Reference

1:The effect of aloe-emodin-induced photodynamic activity on the apoptosis of human gastric cancer cells: A pilot study. Lin HD, Li KT, Duan QQ, Chen Q, Tian S, Chu ESM, Bai DQ.Oncol Lett. 2017 May;13(5):3431-3436. doi: 10.3892/ol.2017.5915. Epub 2017 Mar 27. PMID: 28521449
2:Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species. Dong X, Fu J, Yin X, Yang C, Ni J.Phytother Res. 2017 Apr 26. doi: 10.1002/ptr.5820. [Epub ahead of print] PMID: 28444790
3:Aloe emodin, an anthroquinone from Aloe vera acts as an anti aggregatory agent to the thermally aggregated hemoglobin. Furkan M, Alam MT, Rizvi A, Khan K, Ali A, Shamsuzzaman, Naeem A.Spectrochim Acta A Mol Biomol Spectrosc. 2017 May 15;179:188-193. doi: 10.1016/j.saa.2017.02.014. Epub 2017 Feb 9. PMID: 28242448
4:Aloe-Emodin Enhances Tamoxifen Cytotoxicity by Suppressing Ras/ERK and PI3K/mTOR in Breast Cancer Cells. Tseng HS, Wang YF, Tzeng YM, Chen DR, Liao YF, Chiu HY, Hsieh WT.Am J Chin Med. 2017;45(2):337-350. doi: 10.1142/S0192415X17500215. Epub 2017 Feb 23. PMID: 28231748
5:Aloe-emodin suppresses hypoxia-induced retinal angiogenesis via inhibition of HIF-1α/VEGF pathway. Wu J, Ke X, Wang W, Zhang H, Ma N, Fu W, Zhao M, Gao X, Hao X, Zhang Z.Int J Biol Sci. 2016 Oct 25;12(11):1363-1371. eCollection 2016. PMID: 27877088 Free PMC Article
6:Stealth, biocompatible monoolein-based lyotropic liquid crystalline nanoparticles for enhanced aloe-emodin delivery to breast cancer cells: in vitro and in vivo studies. Freag MS, Elnaggar YS, Abdelmonsif DA, Abdallah OY.Int J Nanomedicine. 2016 Sep 20;11:4799-4818. eCollection 2016. PMID: 27703348 Free PMC Article
7:Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation. Chang X, Zhao J, Tian F, Jiang Y, Lu J, Ma J, Zhang X, Jin G, Huang Y, Dong Z, Liu K, Dong Z.Oncol Lett. 2016 Sep;12(3):2232-2238. Epub 2016 Jul 25. PMID: 27602169 Free PMC Article
8:Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells. Ma JW, Hung CM, Lin YC, Ho CT, Kao JY, Way TD.Oncotarget. 2016 Sep 13;7(37):58915-58930. doi: 10.18632/oncotarget.10410. PMID: 27391337 Free PMC Article
9:Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis. Divya G, Panonnummal R, Gupta S, Jayakumar R, Sabitha M.Eur J Pharm Biopharm. 2016 Oct;107:97-109. doi: 10.1016/j.ejpb.2016.06.019. Epub 2016 Jun 28. PMID: 27368748
10:Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways. Yang M, Li L, Heo SM, Soh Y.Biomol Ther (Seoul). 2016 Jul 1;24(4):395-401. doi: 10.4062/biomolther.2016.020. PMID: 27350340 Free PMC Article