For research use only. Not for therapeutic Use.
Aldumastat (Cat No.:I021751) is an oral, selective inhibitor of ADAM10 and ADAM17, two metalloproteinases involved in the shedding of cell surface proteins that regulate signaling pathways in cancer and inflammation. By blocking these enzymes, aldumastat modulates the activity of substrates such as HER2, TNF-α, and Notch, thereby influencing tumor growth, immune responses, and angiogenesis. Originally investigated in HER2-positive breast cancer, aldumastat has shown potential for enhancing the efficacy of monoclonal antibodies. It represents a promising therapeutic strategy for targeting protease-mediated signaling in cancer and inflammatory diseases.
| CAS Number | 1957278-93-1 |
| Synonyms | (5S)-5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methylpiperazin-1-yl]-3-oxopropyl]imidazolidine-2,4-dione |
| Molecular Formula | C20H24F2N4O3 |
| Purity | ≥95% |
| IUPAC Name | (5S)-5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methylpiperazin-1-yl]-3-oxopropyl]imidazolidine-2,4-dione |
| InChI | InChI=1S/C20H24F2N4O3/c1-12-11-25(6-7-26(12)16-9-14(21)8-15(22)10-16)17(27)4-5-20(13-2-3-13)18(28)23-19(29)24-20/h8-10,12-13H,2-7,11H2,1H3,(H2,23,24,28,29)/t12-,20-/m0/s1 |
| InChIKey | CMLVKUWQFZQPPS-YUNKPMOVSA-N |
| SMILES | C[C@H]1CN(CCN1C2=CC(=CC(=C2)F)F)C(=O)CC[C@@]3(C(=O)NC(=O)N3)C4CC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
