Alda-1

• CAT Number: I003281
• CAS Number: 349438-38-6
• Molecular Formula: C15H11Cl2NO3
• Molecular Weight: 324.2
• Purity: ≥95%
• Target: Dehydrogenase
• Solubility: DMSO: ≥ 51 mg/mL
• Storage: 2-8°C
• IUPAC Name: N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
• InChI: InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)
• InChIKey: NMKJFZCBCIUYHI-UHFFFAOYSA-N
• SMILES: C1OC2=C(O1)C=C(C=C2)CNC(=O)C3=C(C=CC=C3Cl)Cl

Alda-1（Cat No.:I003281） is a small molecule compound known as an ALDH2 agonist. It is capable of activating both the wild-type ALDH21 and the Asian E487K mutant ALDH22 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). Alda-1 is cell-permeable, allowing it to enter cells and interact with the ALDH2 enzyme. By activating ALDH2, Alda-1 enhances the enzyme’s ability to metabolize toxic aldehydes, such as acetaldehyde, thus offering potential therapeutic benefits in conditions associated with aldehyde-induced cellular damage, such as alcohol-related disorders and cardiovascular diseases.

Reference

1:Pretreatment with the ALDH2 agonist Alda-1 reduces intestinal injury induced by ischaemia and reperfusion in mice. Zhu Q, He G, Wang J, Wang Y, Chen W.Clin Sci (Lond). 2017 Jun 1;131(11):1123-1136. doi: 10.1042/CS20170074. Epub 2017 Mar 21. PMID: 28325855 2:Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Stachowicz A, Olszanecki R, Suski M, Głombik K, Basta-Kaim A, Adamek D, Korbut R.Int J Mol Sci. 2017 Feb 17;18(2). pii: E435. doi: 10.3390/ijms18020435. PMID: 28218653 Free PMC Article3:In Vivo Post-Cardiac Arrest Myocardial Dysfunction Is Supported by Ca2+/Calmodulin-Dependent Protein Kinase II-Mediated Calcium Long-Term Potentiation and Mitigated by Alda-1, an Agonist of Aldehyde Dehydrogenase Type 2. Woods CE, Shang C, Taghavi F, Downey P, Zalewski A, Rubio GR, Liu J, Homburger JR, Grunwald Z, Qi W, Bollensdorff C, Thanaporn P, Ali A, Riemer RK, Kohl P, Mochly-Rosen D, Gerstenfeld E, Large S, Ali ZA, Ashley EA.Circulation. 2016 Sep 27;134(13):961-77. doi: 10.1161/CIRCULATIONAHA.116.021618. Epub 2016 Aug 31. PMID: 27582424 4:Alda-1 modulates the kinetic properties of mitochondrial aldehyde dehydrogenase (ALDH2). Belmont-Díaz JA, Yoval-Sánchez B, Calleja-Castañeda LF, Pardo Vázquez JP, Rodríguez-Zavala JS.FEBS J. 2016 Oct;283(19):3637-3650. doi: 10.1111/febs.13833. PMID: 27521998 5:Alda-1 Attenuates Lung Ischemia-Reperfusion Injury by Reducing 4-Hydroxy-2-Nonenal in Alveolar Epithelial Cells. Ding J, Zhang Q, Luo Q, Ying Y, Liu Y, Li Y, Wei W, Yan F, Zhang H.Crit Care Med. 2016 Jul;44(7):e544-52. doi: 10.1097/CCM.0000000000001563. PMID: 26757166 6:The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression. Stachowicz A, Głombik K, Olszanecki R, Basta-Kaim A, Suski M, Lasoń W, Korbut R.Brain Behav Immun. 2016 Jan;51:144-53. doi: 10.1016/j.bbi.2015.08.004. Epub 2015 Aug 4. PMID: 26254233 7:Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. Ikeda T, Takahashi T, Tsujita M, Kanazawa M, Toriyabe M, Koyama M, Itoh K, Nakada T, Nishizawa M, Shimohata T.PLoS One. 2015 Jun 17;10(6):e0128844. doi: 10.1371/journal.pone.0128844. eCollection 2015. PMID: 26083658 Free PMC Article8:Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. Zhong W, Zhang W, Li Q, Xie G, Sun Q, Sun X, Tan X, Sun X, Jia W, Zhou Z.J Hepatol. 2015 Jun;62(6):1375-81. doi: 10.1016/j.jhep.2014.12.022. Epub 2014 Dec 24. PMID: 25543082 9:Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC.Int J Cardiol. 2015 Jan 20;179:129-38. doi: 10.1016/j.ijcard.2014.10.140. Epub 2014 Oct 23. PMID: 25464432 Free PMC Article10:Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. Stachowicz A, Olszanecki R, Suski M, Wiśniewska A, Totoń-Żurańska J, Madej J, Jawień J, Białas M, Okoń K, Gajda M, Głombik K, Basta-Kaim A, Korbut R.J Am Heart Assoc. 2014 Nov 12;3(6):e001329. doi: 10.1161/JAHA.114.001329. PMID: 25392542 Free PMC Article