Albiflorin

• CAT Number: I003431
• CAS Number: 39011-90-0
• Molecular Formula: C23H28O11
• Molecular Weight: 480.46
• Purity: ≥95%
• Solubility: DMSO: ≥ 5.1 mg/mL
• Storage: -20°C
• InChI: InChI=1S/C23H28O11/c1-21-8-13(25)12-7-23(21,33-19-17(28)16(27)15(26)14(9-24)32-19)22(12,20(30)34-21)10-31-18(29)11-5-3-2-4-6-11/h2-6,12-17,19,24-28H,7-10H2,1H3/t12?,13?,14-,15-,16+,17-,19-,21?,22?,23?/m1/s1
• InChIKey: QQUHMASGPODSIW-URSQEBIUSA-N
• SMILES: O=C(OCC1(C2(O[C@@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)CC1C(O)CC2(C)O4)C4=O)C5=CC=CC=C5

Albiflorin is a major constituent contained in peony root; possesses therapeutic potential for neurodegenerative diseases.IC50 value:Target:in vitro: Albiflorin significantly ameliorated Glu-induced reduction of cell viability, nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio. Albiflorin also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3β, and this effect was abrogated by the AKT inhibitor LY294002 [1].in vivo: Mice were exposed to X-ray radiation (400 Roentgen), and both mice and rabbits were intraperitoneally injected with cyclophosphamide (100.0 mg/kg) and cytarabine chloride (92.7 mg/kg), respectively, for 3 days to induce myelosuppression. Albiflorin was subsequently administrated intravenously at low (15.0 mg/kg for mice, 6.00 mg/kg for rabbits), intermediate (30.0 mg/kg for mice, 12.0 mg/kg for rabbits) and high (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) doses, as well as orally (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) for 7 days. Shenqi tablets were used as positive controls (oral administration of 936.0 mg/kg for mice, 336.0 mg/kg for rabbits). The administration of Albiflorin significantly ameliorated myelosuppression in all cases [2].

Reference

1:Anti-PTSD-like effects of albiflorin extracted from Radix paeoniae Alba. Qiu ZK, He JL, Liu X, Zeng J, Chen JS, Nie H.J Ethnopharmacol. 2017 Feb 23;198:324-330. doi: 10.1016/j.jep.2016.12.028. Epub 2016 Dec 16. PMID: 27993636 2:Receptor and transporter binding and activity profiles of albiflorin extracted from Radix paeoniae Alba. Jin ZL, Gao N, Xu W, Xu P, Li S, Zheng YY, Xue M.Sci Rep. 2016 Sep 20;6:33793. doi: 10.1038/srep33793. PMID: 27646789 Free PMC Article3:Albiflorin Granule significantly decreased the cholesterol gallstone formation by the regulation of insulin transduction signal. Fang BJ, Shen JY, Zhang H, Zhou S, Lyu CZ, Xie YQ.Asian Pac J Trop Med. 2016 Sep;9(9):877-81. doi: 10.1016/j.apjtm.2016.07.010. Epub 2016 Aug 4. PMID: 27633302 Free Article4:Protective effects of paeoniflorin and albiflorin on chemotherapy-induced myelosuppression in mice. Zhu YL, Wang LY, Wang JX, Wang C, Wang CL, Zhao DP, Wang ZC, Zhang JJ.Chin J Nat Med. 2016 Aug;14(8):599-606. doi: 10.1016/S1875-5364(16)30070-X. PMID: 27608949 5:Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. Zhou J, Wang L, Wang J, Wang C, Yang Z, Wang C, Zhu Y, Zhang J.Evid Based Complement Alternat Med. 2016;2016:8082753. doi: 10.1155/2016/8082753. Epub 2016 Jun 26. PMID: 27429639 Free PMC Article6:Enhancement of Exposure and Reduction of Elimination for Paeoniflorin or Albiflorin via Co-Administration with Total Peony Glucosides and Hypoxic Pharmacokinetics Comparison. Xu W, Zhao Y, Qin Y, Ge B, Gong W, Wu Y, Li X, Zhao Y, Xu P, Xue M.Molecules. 2016 Jul 1;21(7). pii: E874. doi: 10.3390/molecules21070874. PMID: 27376264 Free Article7:Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice. Zhu Y, Wang L, Yang Z, Wang J, Li W, Zhou J, Zhang J.Evid Based Complement Alternat Med. 2016;2016:5789381. doi: 10.1155/2016/5789381. Epub 2016 May 26. PMID: 27313650 Free PMC Article8:Sensitive analysis and pharmacokinetic study of the isomers paeoniflorin and albiflorin after oral administration of Total Glucosides Of White Paeony Capsule in rats. Fei F, Yang H, Peng Y, Wang P, Wang S, Zhao Y, Huang J, Yu X, Feng S, Sun R, Yang N, Wang H, Aa J, Wang G.J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:30-7. doi: 10.1016/j.jchromb.2016.04.005. Epub 2016 Apr 2. PMID: 27070118 9:Calcium channels contribute to albiflorin-mediated antinociceptive effects in mouse model. Zhang Y, Sun D, Meng Q, Guo W, Chen Q, Zhang Y.Neurosci Lett. 2016 Aug 15;628:105-9. doi: 10.1016/j.neulet.2016.03.054. Epub 2016 Mar 31. PMID: 27038516 10:Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba. Wang YL, Wang JX, Hu XX, Chen L, Qiu ZK, Zhao N, Yu ZD, Sun SZ, Xu YY, Guo Y, Liu C, Zhang YZ, Li YF, Yu CX.J Ethnopharmacol. 2016 Feb 17;179:9-15. doi: 10.1016/j.jep.2015.12.029. Epub 2015 Dec 21. PMID: 26719283