AICAR phosphate

• CAT Number: I004559
• CAS Number: 681006-28-0
• Molecular Formula: C9H17N4O9P
• Molecular Weight: 356.23
• Purity: ≥95%
• Target: AMPK
• Solubility: 10 mM in H2O
• Storage: Store at -20C

AICAR phosphate (Acadesine), is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.Target: AMPKAICAR, also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and Acadesine, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis. Acadesine acts as an AMP-activated protein kinase agonist. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell.

Reference

[1]. Corton JM, et al. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem. 1995 Apr 15;229(2):558-65.
[2]. Favero CB, et al. A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. Brain Res. 2007 Sep 7;1168:1-10. Epub 2007 Jul 27.
[3]. Lemieux K, et al. The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle. FASEB J. 2003 Sep;17(12):1658-65.