For research use only. Not for therapeutic Use.
AI-10-47（Cat No.:I044599）is a selective small-molecule inhibitor that disrupts the interaction between CBFβ and RUNX transcription factors, key regulators of gene expression in hematopoiesis and leukemogenesis. By blocking this protein-protein interaction, AI-10-47 interferes with the function of the RUNX1-CBFβ complex, leading to differentiation and apoptosis of leukemia cells, particularly in acute myeloid leukemia (AML). It has shown strong anti-leukemic activity in preclinical studies without affecting normal hematopoietic cells. AI-10-47 is a valuable tool for studying RUNX-related transcriptional regulation and exploring targeted therapies for hematologic malignancies.
| CAS Number | 1256094-31-1 |
| Synonyms | 2-pyridin-2-yl-6-(trifluoromethoxy)-1H-benzimidazole |
| Molecular Formula | C13H8F3N3O |
| Purity | ≥95% |
| IUPAC Name | 2-pyridin-2-yl-6-(trifluoromethoxy)-1H-benzimidazole |
| InChI | InChI=1S/C13H8F3N3O/c14-13(15,16)20-8-4-5-9-11(7-8)19-12(18-9)10-3-1-2-6-17-10/h1-7H,(H,18,19) |
| InChIKey | JSNWHSDKJSOXET-UHFFFAOYSA-N |
| SMILES | C1=CC=NC(=C1)C2=NC3=C(N2)C=C(C=C3)OC(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
