For research use only. Not for therapeutic Use.
AHR Antagonist 2(CAT: I016820) is a highly potent small-molecule inhibitor of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor involved in xenobiotic metabolism, immunity, and cancer progression. Extracted from patent WO2019101641A1 (compound example 1), this antagonist exhibits nanomolar potency with IC₅₀ values of 0.885 nM for human AHR and 2.03 nM for mouse AHR. By selectively blocking AHR activation, AHR Antagonist 2 serves as a valuable probe for studying AHR-mediated signaling pathways, immune regulation, and environmental toxin responses. It also holds promise in therapeutic research targeting autoimmunity, cancer immunology, and metabolic disease.
| CAS Number | 2338747-54-7 |
| Synonyms | N-[(2S)-1-hydroxypropan-2-yl]-2-pyridin-3-yl-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide |
| Molecular Formula | C20H17F3N4O3 |
| Purity | ≥95% |
| IUPAC Name | N-[(2S)-1-hydroxypropan-2-yl]-2-pyridin-3-yl-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide |
| InChI | InChI=1S/C20H17F3N4O3/c1-12(11-28)25-19(29)17-9-16(26-18(27-17)14-3-2-8-24-10-14)13-4-6-15(7-5-13)30-20(21,22)23/h2-10,12,28H,11H2,1H3,(H,25,29)/t12-/m0/s1 |
| InChIKey | CSSGBPKFVJOAIZ-LBPRGKRZSA-N |
| SMILES | CC(CO)NC(=O)C1=NC(=NC(=C1)C2=CC=C(C=C2)OC(F)(F)F)C3=CN=CC=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
