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AGN 205728

AGN 205728

  • CAT Number: I005160
  • CAS Number: 859498-05-8
  • Molecular Formula: C29H27NO3
  • Molecular Weight: 437.539
  • Purity: ≥95%
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<p style=/line-height:25px/>AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.<br>IC50 value: 3 nM/ 0.6 nM(Ki/IC95)<br>Target: RARγ antagonist<br>More information can be found in the following patent, Compound 7a.<br>Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity<br>By Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.<br>From PCT Int. Appl. (2005), WO 2005066115 A2 20050721.<br></p>

Catalog Number I005160
CAS Number 859498-05-8
Molecular Formula

C29H27NO3

Purity 95%
Target RAR/RXR
Solubility 10 mM in DMSO
Storage Store at -20°C
IC50 3 nM/ 0.6 nM(Ki/IC95)
IUPAC Name 4-[(E,3E)-3-[8,8-dimethyl-5-(4-methylphenyl)-7H-naphthalen-2-yl]-3-hydroxyiminoprop-1-enyl]benzoic acid
InChI InChI=1S/C29H27NO3/c1-19-4-9-21(10-5-19)24-16-17-29(2,3)26-18-23(13-14-25(24)26)27(30-33)15-8-20-6-11-22(12-7-20)28(31)32/h4-16,18,33H,17H2,1-3H3,(H,31,32)/b15-8+,30-27+
InChIKey AUKGBKLQWDXBEP-FSLFYVJCSA-N
SMILES CC1=CC=C(C=C1)C2=CCC(C3=C2C=CC(=C3)C(=NO)C=CC4=CC=C(C=C4)C(=O)O)(C)C
Reference

<p style=/line-height:25px/>
<br>[1]. Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.
</p>

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